Elsevier

Microbes and Infection

Volume 11, Issues 14–15, December 2009, Pages 1197-1205
Microbes and Infection

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Focus on Chikungunya pathophysiology in human and animal models

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Abstract

Chikungunya virus (CHIKV) is an arbovirus responsible for acute febrile arthralgia. It re-emerged abruptly in 2005 and caused a massive outbreak in the Indian Ocean region, and then extended to Asia. Here we review the pathophysiology of CHIKV infection, based on human and mouse studies, and also present prospects for prevention and therapy of this infection. Our results are discussed in the light of the current knowledge regarding other arthritogenic Alphaviruses.

Keywords

Chikungunya
Alphavirus
Mouse model
Cell tropism
Fibroblast
Type 1 interferon
Tissue tropism
Central nervous system infection
Vertical transmission
Neonate infection
Ross River virus
Sindbis virus

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