Isolation and embryonic expression of avian ADAM 12 and ADAM 19
Section snippets
Results and discussion
The ADAM (A Disintegrin And Metalloprotease domain) genes encode large trans-membrane proteins with extracellular metalloprotease, disintegrin- and cysteine-rich domains and a putative intracellular signalling domain. The meltrin sub-family consists of ADAM 12, 13, 19 and 33. ADAM 13 is characterised only in Xenopus, and is expressed in cranial neural crest cells migrating to the branchial arches, and in somitic mesoderm (Alfandari et al., 1997). ADAM 13 perturbation experiments disturb cranial
Materials and methods
Fertile Japanese quail eggs (Coturnix coturnix japonica) (Lago Smallgoods, Melbourne, Australia) were incubated at 37 °C and staged according to Hamburger and Hamilton (1951) for chick embryos. Note that the morphological stage series (denoted HH) of quails is essentially identical to that of chicks, but the chronology of development, denoted by embryonic (E) day, is slightly more rapid.
A quail cDNA fragment with homology to the meltrin class ADAMs was initially obtained by two rounds of
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Differential expression of five members of the ADAM family in the developing chicken brain
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ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects
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