Short communicationMembrane targeting of the small myristoylated protein 2 (SMP-2) in Leishmania major
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Acknowledgements
This work was funded under the NHMRC Project and Program Grants. MJM is a NHMRC Principal Research Fellow.
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Cited by (2)
Potential application of small myristoylated protein-3 evaluated as recombinant antigen and a synthetic peptide containing its linear B-cell epitope for the serodiagnosis of canine visceral and human tegumentary leishmaniasis
2019, ImmunobiologyCitation Excerpt :In this study, SMP-3 presented a 2.48-time reduction in their expression content, when parasites were in vitro cultured for 150 days. Leishmania parasites express a conserved family of small myristoylated proteins (SMPs), which share an identical central domain but contain differential acylation signals and distinct C-terminal subdomains, being target to distinct regions of the plasma membrane including the cell body, flagellum and flagellar pocket (Tull et al., 2012; Heng et al., 2013). The most of SMPs appear to have unknown function in Leishmania (Tull et al., 2004); however, some family proteins, such as SMP-1, showed to be required for flagellar function, since the inhibition of the expression of this protein resulted in flagellum retraction and uncoordinated movements by parasites (Tull et al., 2010).
Acylation in trypanosomatids: An essential process and potential drug target
2014, Trends in Parasitology
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Current address: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.
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Equal senior authors.