Original ArticleHepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis
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Keywords
Dietary fats
Protein kinase cβ
Hepatic steatosis
Mitochondria respiratory chain
Abbreviations
AKT
protein kinase B
FCCP
trifluoromethoxy carbonyl cyanide phenylhydrazine
HFD
high-fat diet
IRS
insulin receptor substrate
MEK
mitogen-extracellular kinase
mTOR
mechanistic target of rapamycin
OCR
oxygen consumption rate
PKCβ
protein kinase Cβ
PKCβfl/fl
floxed PKCβ mice
PKCβHep−/−
hepatocyte-specific PKCβ-deficient mice
SREBP-1c
sterol response element-binding protein-1c
TG
triglycerides
VLDL
very low-density lipoproteins
WAT
adipose tissue
Cited by (0)
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Yaoling Shu and Faizule Hassan contributed equally to this work.
© 2020 The Authors. Published by Elsevier GmbH.