P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus
Section snippets
Acknowledgments
The authors thank Dr. Gillian E. Knight for her excellent editorial assistance. We also thank Roche Bioscience, Palo Alto, CA for kindly supplying P2X antisera and peptides. This work was supported by the National Natural Science Foundation of PR China (30670639 to Z. Xiang).
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Purinergic signaling pathways in endocrine system
2015, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :P2X2 and P2X4 subunits are expressed in monkey GnRH neurons (Terasawa et al., 2005) and this was confirmed in mouse and rat by immunohistochemical analysis done in Burnstock's lab (Loesch and Burnstock, 2001; Loesch et al., 1999; Xiang et al., 1998). They also found the presence of P2X5R and P2X6R immunoreactivity in mouse GnRH neurons (Fu et al., 2009). Transgenic mice and rats expressing GFP-labeled GnRH neurons provide a promising system to investigate the expression and role of purinergic receptors in GnRH neurons more directly.
P2X2 purinoreceptor protein in hypothalamic neurons associated with the regulation of food intake
2010, NeuroscienceCitation Excerpt :The chemical phenotypes of P2X2Rs in the hypothalamus have been investigated earlier. P2X2R protein has been demonstrated in neurons containing luteinizing hormone-releasing hormone (LHRH) in the area around the organum vasculosum of lamina terminals (OVLT) (Fu et al., 2009), and in vasopressin and oxytocin neurons of the supraoptic nucleus (Guo et al., 2009). P2X2Rs have also been observed in neurons of the supraoptic nucleus containing NOS (Yao et al., 2003).
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2017, Frontiers in Endocrinology
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These two authors contributed equally to this work.