Elsevier

Neuroscience Letters

Volume 581, 3 October 2014, Pages 46-51
Neuroscience Letters

Paraoxonase 1 status and interactions between Q192R functional genotypes by smoking contribute significantly to total plasma radical trapping antioxidant potential

https://doi.org/10.1016/j.neulet.2014.08.020Get rights and content
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Highlights

  • TRAP and PON1, 197 healthy, 91 with unipolar depression and 45 with bipolar disorder.

  • PON1, male gender, RR genotype and body mass index are inversely correlated with TRAP.

  • PON1 activity, interactions between PON1 Q192R genotypes and smoking influence TRAP.

Abstract

The measurement of the total radical trapping antioxidant potential (TRAP) is a general marker of peripheral blood antioxidant defenses. Paraoxonase 1 (PON1) is a potent antioxidant, which protects against lipid peroxidation. The study aimed to examine the relation between TRAP levels and PON1 activity, PON1 Q192R functional genotypes, smoking, interactions between PON1 genotypes and smoking, and mood disorders, while adjusting for effects of ethnicity, marital status, body mass index (BMI) and gender. The analyses were performed in 197 controls and 136 subjects with mood disorders. TRAP levels were significantly associated with higher plasma PON1 activity, the RR functional genotype, non smoking by RR carriers, male gender and a higher BMI. TRAP levels were significantly lower in patients with mood disorders than in controls, but this association was no longer significant after considering the effects of the above predictors. The risk in the subgroup with low TRAP levels is increased by a smoking X RR genotype interaction and decreased by male gender, the RR genotype, and higher BMI and PON1 activity. Plasma PON1 activity, the PON1 Q192R functional genotypes and specific interactions between this genotype and smoking contribute significantly to TRAP levels. Gender and BMI also appear to influence TRAP levels.

Abbreviations

ANCOVAs
analysis of covariance
ANOVAs
analysis of variance
ASSIST
alcohol, smoking and substance involvement screening
BD
bipolar disorder
BMI
body mass index
CMPA
4-chloromethyl phenol acetate
DSM-IV
diagnostic and statistical manual of mental disorder
GLM
general linear analysis
HDL
high-density lipoprotein
HDRS
Hamilton depression rating scale
LDL
low-density lipoprotein
OS
oxidative stress
PA
phenyl acetate
PON1
paraoxonase 1
ROS
reactive oxygen species
SEM
standard error of the mean
TRAP
total radical trapping antioxidant potential
TUD
tobacco use disorder

Keywords

Paraoxonase
Smoking
TRAP
Depression
Body mass index
Psychiatry

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