The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex
Section snippets
Participants
The sample comprised 24 (12 male, 12 female) participants with no personal or family history of psychiatric or neurological illness who were pre-selected based on their PCS morphology. Our previous work (Yücel et al., 2001, Yücel et al., 2002a, Yücel et al., 2002b, Yücel et al., 2003a, Fornito et al., 2004) has used a three-category classification system for the PCS, denoting it as being either ‘absent’, ‘present’, or ‘prominent’, based on its rostro-caudal extent. In a large normative sample (n
Reliability analysis
To ensure generalizability of the protocol, reliabilities were studied in a separate sample of 15 randomly selected individuals comprising cases with both symmetric and asymmetric PCS patterns. Most ICCs were > 0.90, and none < 0.80, indicating that the method provides a reliable means for measuring ACC volume while considering inter-individual variations in sulcal and gyral anatomy. Intra- and inter-rater reliabilities for each region are presented in Table 1.
Volumetric comparisons
Mean volumes for each subregion in
Discussion
This study presented a reliable method for parcellating the ACC and PaC into distinct and functionally relevant subregions while considering variations in sulcal and gyral anatomy. Previous morphometric studies have typically focused only on the ACC (Haznedar et al., 1997, Szeszko et al., 1999a, Szeszko et al., 1999b, Pujol et al., 2002, Miller et al., 2003, Rauch et al., 2003, Zhou et al., 2005) or failed to account for PCS variability when measuring the PaC (Caviness et al., 1996,
Acknowledgments
The authors would like to thank Dr. Sue Cotton and Mr. Anthony Ang for helpful discussions regarding the manuscript. This research was supported by the Melbourne Neuropsychiatry Centre (Sunshine Hospital), Department of Psychiatry, the University of Melbourne, the National Health and Medical Research Council (ID 236175; 350241), and the Ian Potter Foundation. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms. Bridget Soulsby at the Melbourne
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