Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain
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Research highlights
► Investigated preparation and MR parameters for contrast-enhanced mouse brain imaging. ► Also investigated correlates of active-staining for optimised imaging of mouse brain. ► In-situ brains scanned with optimised parameters enabled detailed, high SNR images. ► Correlated MR brain structures to histology, detailing fine histoarchitecture visible. ► Our findings may provide insights into the cellular distribution of MR active-stains.
Abbreviations
MRI
magnetic resonance imaging
CNS
central nervous system
Gd-DTPA
gadolinium-diethylene-triamine-pentaacetic acid
SNR
signal-to-noise ratio
CNR
contrast-to-noise ratio
FOV
field of view
NSA
number of signal averages
TE
echo time
TR
repetition time
FA
flip angle
Keywords
Magnetic resonance microscopy
Mouse brain phenotyping
Active staining
Mouse brain histology
Immunohistochemistry
Myelin
Grey matter
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Copyright © 2011 Elsevier Inc.