Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities
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Graphical Abstract
Keywords
Fixel-Based Analysis
Diffusion MRI
Fixel
White matter
Microstructure
Fibre density
Fibre-bundle cross-section
Statistical analysis
Abbreviations
AFD
apparent fibre density
BEDPOSTX
Bayesian estimation of diffusion parameters obtained using sampling techniques with modelling of crossing fibres
CFE
connectivity-based fixel enhancement
CHARMED
composite hindered and restricted model of diffusion
CSD
constrained spherical deconvolution
CSF
cerebrospinal fluid
dMRI
diffusion magnetic resonance imaging
DTI
diffusion tensor imaging
EPI
echo-planar imaging
FA
fractional anisotropy
FC
fibre-bundle cross-section
FD
fibre density
FDC
fibre density and cross-section
Fixel
a specific fibre population within a voxel
FBA
fixel-based analysis
FBM
fixel-based morphometry
FLAIR
fluid-attenuated inversion recovery
FOD
fibre orientation distribution
FWE
family-wise error
FWHM
full width at half maximum
GM
grey matter
HARDI
high angular resolution diffusion imaging
MD
mean diffusivity
MRI
magnetic resonance imaging
MSMT-CSD
multi-shell multi-tissue constrained spherical deconvolution
NODDI
neurite orientation dispersion and density imaging
ROI
region-of-interest
SNR
signal-to-noise ratio
SS3T-CSD
single-shell 3-tissue constrained spherical deconvolution
SWI
susceptibility-weighted imaging
TBM
tensor-based morphometry
TBSS
tract-based spatial statistics
TFCE
threshold-free cluster enhancement
VBA
voxel-based analysis
VBM
voxel-based morphometry
WM
white matter
Cited by (0)
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Adam Clemente and Mervyn Singh contributed equally to this work.
© 2021 The Authors. Published by Elsevier Inc.