Original articleThe Heritability of Corneal Hysteresis and Ocular Pulse Amplitude: A Twin Study
Section snippets
Patients and Methods
Two hundred seventy-two pairs of healthy twins, mean age of 54.1 years (range, 16–78 years), were recruited from the TwinsUK Adult Twin Registry, held at St. Thomas' Hospital, London. They were unaware of any hypotheses or proposals for specific studies; only later were they invited to have an eye examination. The institutional ethics committee approved the study, and all the patients gave informed consent. Zygosity was determined by a standardized questionnaire16 and was confirmed by DNA
Results
Of the original 272 pairs of twins recruited, 8 pairs were excluded: 5 pairs because one or both twins had undergone excimer laser refractive surgery and the other 3 pairs because one of each pair could not undergo the tests. Thus, 264 twin pairs (135 MZ, 129 DZ) were included in the analysis; all were white and 92.5% were female. The overall mean of all 4 corneal hysteresis readings for each individual was10.24±1.54 mmHg. Corneal hysteresis measurements for right and left eyes correlated
Discussion
The authors demonstrated that both ocular pulse amplitude and corneal hysteresis, which play a role in glaucoma and IOP,6, 17 are strongly influenced by genes. Despite a similar distribution of CCT in an Asian population, tonometric measurement of cannulated Asian eyes revealed lower applanation IOP readings compared with that of Europeans.6 One possible explanation is that eyes with the same CCT may differ in elastic responsiveness (corneal hysteresis) because of ethnic variation, and this may
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Manuscript no. 2007-1383.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.
Supported by a grant from The Guide Dogs for The Blind Association, Berkshire, United Kingdom.