Original articleMacular and Nerve Fiber Layer Thickness in Amblyopia: The Sydney Childhood Eye Study
Section snippets
Study Population
The Sydney Childhood Eye Study (incorporating the Sydney Myopia Study) was a population-based survey that examined childhood eye conditions in Year 1 (median age 6 years) and Year 7 (median age 12 years) students. It was approved by the Human Research Ethics Committee, University of Sydney, the Department of Education and Training, and the Catholic Education Office, New South Wales, Australia. The study adhered to the tenets of the Declaration of Helsinki.
Detailed study methods have been
Results
Of 4118 children examined, complete optical coherence tomography scan data were available in 3529 children (85.7%), 1395 (39.5%) of whom were Year 1 students. Both peripapillary RNFL and macular thickness data were available in 3094 students; 293 students had peripapillary RNFL but not macular scans, and 142 students had macular but not peripapillary RNFL scans.
The overall prevalence of amblyopia was 1.84% (n = 65). There was no significant difference in prevalence between the 6-year-old Year 1
Discussion
Our population-based study found slight differences in macular thickness, as measured by optical coherence tomography, between amblyopic and non-amblyopic eyes. Among all children with amblyopia, foveal minimum thickness was slightly greater (by ∼5 μm) in the amblyopic than the normal fellow eye. This difference was more apparent in 6-year-old children (6.9 μm) than 12-year-old children (4.2 μm). The foveal minimum and central macula were thicker, but the inner macular ring was thinner in
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2024, American Journal of OphthalmologyRole of optical coherence tomography in unilateral amblyopia
2023, Journal Francais d'OphtalmologieHow do the amblyopic and fellow eyes differ in adults?
2022, Journal Francais d'OphtalmologieCitation Excerpt :Notably, advances in optical coherence tomography [OCT] devices have increased this interest in amblyopia. However, results of the studies conducted so far differ, and there is no general consensus on the effects of amblyopia [6,7]. In this study, we aimed to make an additional contribution to the literature by examining the OCT and biometry data of patients who were followed up with a diagnosis of anisometropic amblyopia in our clinic and examining the differences that exist between the amblyopic eye and the fellow eye.
Manuscript no. 2008-1044.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the Australian National Health and Medical Research Council, Canberra, Australia (Grant 253732) and the Vision Co-operative Research Centre.