Original articleDiagnostic Ability of Heidelberg Retina Tomography in Detecting Glaucoma in a Population Setting: The Singapore Malay Eye Study
Section snippets
Population Sampling
The Singapore Malay Eye Study (SiMES) examined 3280 persons (78.7% response) of Malay ethnicity aged 40 to 80 years between August 2004 and June 2006.4, 15 The methods for this survey and recruitment process have been described in detail.16 Ethics approval was obtained from the institutional review board of the Singapore Eye Research Institute, Singapore, and the study was conducted in accordance with the World Medical Association's Declaration of Helsinki. Informed written consent was obtained
Results
Of the 3280 participants, HRT II was performed on 3131 subjects, of whom 75 were unable to complete the test (mostly because of cataract, poor fixation and visual acuity, or strabismus) and 8 had optic disc abnormalities (6 with myelinated nerve fibers, 1 with flame hemorrhage, and 1 with Bergmeister papilla). Of the remaining 3048 subjects (5908 eyes), acceptable HRT images were obtained from 4921 eyes of 2775 participants (both eyes of 2146 participants, right eyes of 316 participants, and
Discussion
Screening for glaucoma remains a controversial issue.30, 31, 32 This is partly attributable to the absence of an effective screening tool, the relatively low prevalence of the late stages of the disease, and the uncertainty about whether screening would benefit visual function and improve quality of life for those diagnosed with glaucoma. Our previous report of Singapore Malays showed that 3.8% of persons had glaucoma and that more than 90% of cases with glaucoma were previously undiagnosed.4,
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Cited by (18)
Economics of Glaucoma Care
2015, Glaucoma: Second EditionThe value of tests in the diagnosis and management of glaucoma
2011, American Journal of OphthalmologyCitation Excerpt :Population-based studies have consistently shown that traditional screening tests—Goldmann tonometry, automated visual fields, and evaluation of the disc—do not provide adequate positive predictive value for the efficient detection of open-angle glaucoma.9,18 There seems little promise from more recent population-based studies that new technologies—such as retinal tomography19,20 and frequency-doubling technology21,22— will improve this situation soon. A recent Cochrane review could find no randomized controlled trials demonstrating the benefit of screening for open-angle glaucoma,23 and a single such trial for angle closure and angle-closure glaucoma has reported a negative result.24
Influence of refractive error on optic disc topographic parameters: The Singapore malay eye study
2011, American Journal of OphthalmologyCitation Excerpt :Magnification errors were corrected using subjects' refractive status and corneal curvature measurements. All HRT II examinations were performed by 2 trained operators.21,22 The HRT II optic nerve head scan protocol generates a mean topographic image with a resolution of 384 × 384 generated from 3 individual topographic images.
Determinants of image quality of heidelberg retina tomography II and its association with optic disc parameters in a population-based setting
2011, American Journal of OphthalmologyCitation Excerpt :Corneal curvature radius was entered in the HRT II software and cylindrical lens was adapted for those who had astigmatism greater than or equal to 1.0 D. After completion of the SiMES, the optic disc margin (inner edge of Elschnig's ring) was manually defined by a trained ophthalmologist (S.C.L.).13 This critical step was accomplished by plotting a series of dots around the margin of disc on the reflectance image provided by the computer.
Manuscript no. 2009-87.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the National Medical Research Council Grants No 0796/2003 and Biomedical Research Council Grant No 501/1/25-5.