Original articleLens Vault, Thickness, and Position in Chinese Subjects with Angle Closure
Section snippets
Patients and Methods
This was a prospective, comparative study of Chinese subjects with angle closure attending a glaucoma clinic and of normal control subjects recruited from an ongoing population-based study.11 Written informed consent was obtained from all subjects, and the study had the approval of the Institutional Review Board of Singapore Eye Research Institute and was performed in accordance with the tenets of the Declaration of Helsinki.
A case of angle closure was defined as primary angle closure (PAC),
Results
A total of 102 angle-closure subjects (consisting of 29 PAC, 53 PACG, and 20 previous APAC subjects) and 176 normal control subjects were recruited for the study. All subjects were of Chinese ethnicity. Angle-closure subjects were older (65.3±9.1 years vs. 54.2±7.9 years; P<0.001), and there were proportionately more females (66.7% vs. 46.6%; P = 0.001) compared with normals. For the normal control group, LV increased significantly with advancing age (P<0.001, for trend; Table 1, available at //aaojournal.org
Discussion
As far as the authors are aware, this is the first study to describe the LV as a unique and possibly independent ocular parameter associated with angle closure. This supports the concept that increased thickness and bulk of the lens anterior to the plane of the scleral spur pushes the peripheral iris against the trabecular meshwork, worsening angle crowding in an already predisposed eye. Increased LV likely increases the amount of iridolenticular contact, leading to a more pronounced iris
References (24)
- et al.
Age, gender, biometry, refractive error, and the anterior chamber angle among Alaskan Eskimos
Ophthalmology
(2003) - et al.
Ultrasound biomicroscopic and conventional ultrasonographic study of ocular dimensions in primary angle-closure glaucoma
Ophthalmology
(1998) - et al.
The ratio of lens thickness to axial length for biometric standardization in angle-closure glaucoma
Am J Ophthalmol
(1985) A physical analysis of the factors that determine the contour of the iris
Am J Ophthalmol
(1991)- et al.
The physiologic characteristics of relative pupillary block
Am J Ophthalmol
(1991) - et al.
The effect of iridotomy on iris contour
Am J Ophthalmol
(1990) - et al.
Optical coherence tomography quantitative analysis of iris volume changes after pharmacologic mydriasis
Ophthalmology
(2010) - et al.
Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations
Arch Ophthalmol
(2005) - et al.
Determinants of angle closure in older Singaporeans
Arch Ophthalmol
(2008) - et al.
Screening techniques for angle-closure glaucoma in rural Taiwan
Acta Ophthalmol Scand
(1996)
Ocular dimensions in the heredity of angle-closure glaucoma
Br J Ophthalmol
Aetiology of the anatomical basis for primary angle-closure glaucoma: biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma
Br J Ophthalmol
Cited by (289)
Progressive Changes in the Anterior Segment and Their Impact on the Anterior Chamber Angle in Primary Angle Closure Disease
2024, American Journal of OphthalmologyDeep Learning-based Quantification of Anterior Segment OCT Parameters
2024, Ophthalmology ScienceDeep Learning Classification of Angle Closure based on Anterior Segment OCT
2024, Ophthalmology GlaucomaRole of Static and Dynamic Ocular Biometrics Measured in the Dark and Light as Risk Factors for Angle Closure Progression
2023, American Journal of OphthalmologyAdvances in swept-source optical coherence tomography and optical coherence tomography angiography
2023, Advances in Ophthalmology Practice and Research
Manuscript no. 2010-268.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
Tin Aung - Financial Support - Carl Zeiss Meditec
Tien Yin Wong - Financial Support - Carl Zeiss Meditec
David S. Friedman and Scott D. Smith - Instrument Loan - Carl Zeiss Meditec
Supported by Singhealth, Singapore, Republic of Singapore; National Medical Research Council, Singapore, Republic of Singapore; and the National Research Foundation, Singapore, Republic of Singapore.