Original articleRelationship between Retinal Microstructures on Optical Coherence Tomography and Microperimetry in Age-Related Macular Degeneration
Section snippets
Methods
This study was approved by the Human Research Ethics Committee of the Royal Victorian Eye and Ear Hospital and was conducted in accordance with the Declaration of Helsinki; written informed consent was obtained from all participants.
Results
A total of 75 participants with intermediate AMD were included in this study (68.2±8.5 years; range, 54–87 years), 53 (71%) of whom were female. Because all participants had intermediate AMD in both eyes, 1 eye was randomly selected to be the study eye; 35 right and 40 left eyes were included from these participants. Twenty-five control participants were included to determine the normal values for microperimetry (64.9±5.2 years; range, 50–73 years), 14 (66%) of whom were female; there were no
Discussion
This study showed that the integrity of the ISe band and RPE elevation were significant independent predictors of local changes in microperimetric retinal sensitivity, but not the OS length, RPE thickness, or presence of HF. By using a simple linear model that combined ISe grading and RPE elevation, the 95% limits of agreement between the predicted and measured retinal sensitivity is ±3.83 dB. The close correlation of these structural parameters with retinal function is ideal when considering
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the National Health and Medical Research Council (NH&MRC) Project Grant (1027624), NH&MRC practitioner fellowship (RHG, #529905), Macular Disease Foundation Australia Research Grant, Bupa Health Foundation (Australia), William Angliss (Victoria) Charitable Fund Research Grant, BrightFocus Foundation, The Perpetual Trust Foundation and MR & RA Brownless Perpetual Charitable Trust funding administered by the Trust Company. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government. This study was supported by the NH&MRC Centre for Clinical Research Excellence #529923 – Translational Clinical Research in Major Eye Diseases.
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C.D.L. and R.H.G. contributed equally as senior authors.