CommentaryAre We Closer to Understanding Developmental Outcomes from Intravitreal Bevacizumab Therapy for Retinopathy of Prematurity?
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Cited by (2)
Assessment and management of retinopathy of prematurity in the era of anti-vascular endothelial growth factor (VEGF)
2022, Progress in Retinal and Eye ResearchCitation Excerpt :Premature infants with a history of ROP treatment with bevacizumab had similar refractive, visual, and neurodevelopmental outcomes compared to premature patients with ROP that did not require treatment. However, the exclusion criteria were extensive and differences in groups may have been missed in this study enrolling 148 patients (CARDEN, 2019). Further, two separate meta-analyses in 2020 yielded conflicting results regarding whether bevacizumab for severe ROP leads to neurodevelopmental impairment (KAUSHAL; RAZAK; PATEL; PULLATTAYIL et al., 2021; TSAI; YEH; TSAO; CHUNG et al., 2021).
Retinopathy of Prematurity: Evolving Treatment With Anti–Vascular Endothelial Growth Factor
2020, American Journal of OphthalmologyCitation Excerpt :A meta-analysis of several clinical studies that addressed this question showed a benefit of erythropoietin for neuroprotection, but the recent PENUT clinical trial, which had stringent enrollment criteria, did not find value of early erythropoietin treatment on neurocognitive outcomes in children at 2 years of age.33 The studies as of this writing testing anti-VEGF in preterm infants have been retrospective or may have excluded infants at the greatest risk.32 Currently, few, if any, studies have evaluated the effect of anti-VEGF on the neural retina, including by optical coherence tomography.
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