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Elucidating Host Cell Uptake by Malaria Parasites

https://doi.org/10.1016/j.pt.2019.03.005Get rights and content

The malaria parasite must digest host cytoplasm for normal growth, and many studies have revealed the essential role of proteases in hemoglobin digestion. Here, we discuss the results of Jonscher et al. (Cell Host Microbe 2019;25:166–173) who have, for the first time, identified a molecule, VPS45, involved in the uptake and trafficking of host cytoplasm to the digestive vacuole.

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Acknowledgments

Brendan Elsworth was supported by an Australian National Health and Medical Research Council C.J. Martin fellowship (No. 1148392). Caroline D. Keroack was supported by a National Institute of Health, USA, training grant (No. 5T32AI49928-13).

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