Elsevier

Redox Biology

Volume 59, February 2023, 102561
Redox Biology

Molecular properties and regulation of NAD+ kinase (NADK)

https://doi.org/10.1016/j.redox.2022.102561Get rights and content
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Highlights

  • NADK phosphorylates NAD+, thereby producing NADP(H).

  • NADK plays a crucial role in anabolic process and redox homeostasis through production of NADP(H).

  • NADK is regulated by posttranslational modifications such as phosphorylation.

  • NADK could be a therapeutic target in human disease, such as cancer.

Abstract

Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria, plants and mammals. In mammals, NADK is activated by phosphorylation and protein-protein interaction. Recent studies conducted using genetically altered models validate the essential role of NADK in cellular redox homeostasis and metabolism in multicellular organisms. Here, we describe the evolutionary conservation, molecular properties, and signaling mechanisms and discuss the pathophysiological significance of NADK.

Keywords

NADK
NADK2
NAD+
NADPH
Thioredoxin
Nampt

Data availability

No data was used for the research described in the article.

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