Platelets in equine recurrent airway obstruction

https://doi.org/10.1016/j.rvsc.2006.09.007Get rights and content

Abstract

Platelets contribute to the pathogenesis of human allergic airway disease. The aim of this study was to compare platelet activating factor (PAF)-induced platelet aggregation and thromboxane (Tx) production, plasma Tx and 5-hydroxytryptamine (5-HT) in ponies with recurrent airway obstruction (RAO), an hypersensitivity to inhaled antigens, and normal ponies, before and after antigen exposure. Plasma 5-HT was significantly higher in ponies with RAO but was not further increased by antigen challenge. There was no difference between PAF-induced platelet aggregation or Tx production, or in plasma Tx before or after challenge. These data suggest there may be a difference between platelet 5-HT uptake in RAO and normal ponies but do not provide evidence of platelet activation following antigen exposure.

References (14)

  • C.C. Lalko et al.

    Equine platelet CD62P (P-selectin) expression: a phenotypic and morphologic study

    Veterinary Immunology and Immunopathology

    (2003)
  • J.M. Ablett et al.

    Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease

    Equine Veterinary Journal

    (1997)
  • S.R. Bailey et al.

    Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis

    Equine Veterinary Journal.

    (1998)
  • S.R. Bailey et al.

    Differential activation of platelets from normal and allergic ponies by PAF and ADP

    Inflammation Research

    (2000)
  • S.R. Bailey et al.

    Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum

    Equine Veterinary Journal

    (2003)
  • T.J. Brazil et al.

    Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation

    Clinical and Experimental Allergy

    (2005)
  • P. Eyre

    Equine pulmonary emphysema: a bronchopulmonary mould allergy

    Veterinary Record

    (1972)
There are more references available in the full text version of this article.

Cited by (8)

  • Effect of antigen challenge on dynamics of CD62P and CD41/61 expression on platelets in horses with recurrent airway obstruction (RAO)

    2018, Veterinary Immunology and Immunopathology
    Citation Excerpt :

    That was not observed in control horses. The results support observations made in several studies, which demonstrated the activation and accumulation of neutrophils in the lungs and airways of horses with RAO in response to an antigen challenge (Dunkel et al., 2007, 2010, Fairbairn et al., 1993a,b, 1996, Hammond et al., 2007; Marr et al., 2002). Even in horses with clearly abnormal diagnostic findings and a history of RAO, the majority of owners reported satisfaction with the clinical status of their horses (Rettmer et al., 2015).

  • Expression of surface platelet receptors (CD62P and CD41/61) in horses with recurrent airway obstruction (RAO)

    2015, Veterinary Immunology and Immunopathology
    Citation Excerpt :

    Recurrent airway obstruction (RAO), also known as heaves, is an allergic disease of horses similar to human asthma, that develops in susceptible horses following stabling and hay dust exposure (Cunningham and Dunkel, 2008; Dunkel et al., 2009; Leguillette, 2003; Hammond et al., 2007; Moran and Folch, 2011).

  • The influence of age on plasma serotonin levels in Thoroughbred horses

    2012, Livestock Science
    Citation Excerpt :

    Horse plasma levels (Di Pietro et al., 2010; Haritou et al., 2008; Lebelt et al., 1998) are higher than human plasma (Brenner et al., 2007). The increase of plasma 5-HT is often related to common horse pathologies as acute laminitis (Bailey et al., 2009) and recurrent airway obstruction in ponies (Hammond et al., 2007). 5-HT also plays an important role as an intestinal secretagogue in gastrointestinal disorders such as gastric ulcers, diarrhea and colic in newborn foals and adult horses (Delesalle et al., 2008; Fink et al., 2006).

  • The physiopathological features of serotonin in horses

    2018, Serotonin and Dopamine Receptors: Functions, Synthesis and Health Effects
View all citing articles on Scopus
1

Present address: Mayes and Scrine, Dawes Farm, Bognor Road, Warnham, West Sussex RH12 3SH, UK. A. Hammond was recipient of a Clinical Training Scholarship from the Horserace Betting Levy Board.

View full text