Association between circulating angiotensin-converting enzyme and exercise-induced pulmonary haemorrhage in Thoroughbred racehorses
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Cited by (3)
Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses
2017, Research in Veterinary ScienceCitation Excerpt :Furthermore, heart valve regurgitation is associated with an activation of the renin angiotensin aldosterone axis (Gehlen et al., 2002). In a preliminary report, Costa et al. (2012) also found greater serum ACE activity in horses with exercise-induced pulmonary hemorrhage; therefore, it might be a promising marker of this condition. However, this together with the vasodilatory effects might lead to fraudulent administration of these pro-drugs despite the fact that they are a prohibited (benazepril) or controlled (enalapril) medication according to the FEI (Fédération Equestre Internationalle).
Bronchoalveolar lavage fluid in Standardbred racehorses: Influence of unilateral/bilateral profiles and cut-off values on lower airway disease diagnosis
2014, Veterinary JournalCitation Excerpt :Firstly described by the presence of post-exertional epistaxis in severe cases (Cook, 1974), different diagnostic methods for EIPH have been used. These include post-exercise tracheobronchoscopic evaluation of blood (Pascoe et al., 1981; MacNamara et al., 1990; Lapointe et al., 1994; Birks et al., 2002; Hinchcliff et al., 2005a; Costa et al., 2012), or detection/quantification of erythrocytes (Langsetmo et al., 2000; Epp et al., 2006; McKane and Slocombe, 2010) and/or haemosiderophages (Fogarty and Buckley, 1991; McKane et al., 1993; Langsetmo et al., 2000; Doucet and Viel, 2002; Newton and Wood, 2002; Sanchez et al., 2005) in respiratory fluids. Recommendations still differ regarding the method of choice for diagnosing EIPH, and no methods reported so far allow for an accurate evaluation of the severity of bleeding (Derksen et al., 2011).
Exercise-induced pulmonary haemorrhage in horses -review
2013, Acta Veterinaria Brno