Structure
Volume 29, Issue 6, 3 June 2021, Pages 512-514
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Distinction between self and non-self in restriction modification: The mysterious case of type IIL enzymes

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Most type II restriction modification systems employ rigorous mechanisms to interrogate methylation in both DNA strands to distinguish between host and invader DNA. Type IIL enzymes like DrdV are an exception to this rule. In this issue of Structure, Shen et al. (2021) address how such enzymes make the distinction successfully.

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