Elsevier

Tetrahedron Letters

Volume 49, Issue 5, 28 January 2008, Pages 786-789
Tetrahedron Letters

Stereoselective synthesis of the C33–C44 fragment of palau’amide

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Abstract

An efficient stereoselective synthesis of the C33–C44 fragment of palau’amide is described using a Sharpless asymmetric epoxidation, a regioselective nucleophilic ring opening of the epoxide, a Grignard reaction and a Luche stereoselective reduction of a keto compound as the key steps.

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Acknowledgements

We thank Dr. Mukund K. Gurjar for his support and encouragement. S.N. thanks CSIR, New Delhi, for financial support in the form of a research fellowship. We also thank Dr. P. R. Rajmohanan for the NMR data.

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