Jetlag related sleep problems and their management: A review
Introduction
Jet lag normally impacts air passengers who pass numerous time belts. It consequences from the body's internal rhythms being out of sync with the day-night cycle at the designation in which the traveler arrives. Melatonin is a pineal hormone that performs a primary part in adjusting physical rhythms and has commonly been prescribed as a drug to reorient these rhythms with their surroundings [1].
Travelling across several continents through various longitudes results in flight dysrhythmia, known as jet lag. Signs of jet lag can vary between debilitated awareness, insomnia, feeling tired during the day and frequent waking during the night. Such factors as the individual travelling, the count of time belts that have been passed and the route of the journey are significant elements that affect the severity of jet lag symptoms [2].
The signs of flight dysrhythmia are commonly exhaustion throughout the day and disturbances in sleep patterns; however additionally encompass loss of mental performance, weakness and irritability [3]. The reason for jet lag is due to the disharmonizing of the body's circadian structure and the day to night cycle of the destination the passenger has travelled to. Loss of sleep throughout the travel period is an additional factor in jetlag. Once passengers have flown over 6 or more time longitudes, it will take them between 4 and 6 days to resume their ordinary sleeping patterns and to feel less lethargic throughout the day. It is important to note that the number of time zones surpassed and in which direction these zones were contribute to the harshness of jetlag [1].
Travel towards the East induces a phase advance in the body's circadian rhythms, whereas westbound travel creates the reversed effect [4]. Ergo, people who fly westbound adjust their bodily rhythms at the speed of one and half hours per day, whereas eastbound passengers do so at one hour per day. This applies to both daytime and nighttime travels. Another important aspect to take note of is that jet lag and the disturbance of the circadian rhythm could also aggravate pre existing disorders associated with the above [2,5].
Section snippets
Circadian rhythm
Humans function as diurnal beings in which their biological clocks adjust to their physiological activities; functions related to any form of activity would take place during the day, while anything related to rest would transpire at night. Daylight and artificial light are the principle environmental indication utilized by the circadian clock to ascertain this adjustment of day to night time cycles [6].
Strong corporeal and biochemical rhythms are evident in all live organisms [7,8]. These
Anatomy
The principal pacemaker of the mammalian circadian system is found in the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN comprise of cells that alter their heights of activity dependent on the velocity of the surrounding light [27]. These cells are highly responsive to the environmental degree of lights and are able to consolidate light exposure over distinctly lengthy durations of time. The light signal reaches the SCN mainly through the retinohypothalamic tract (RHT). It is
Melatonin
The melatonin hormone is excreted by the pineal gland when darkness descends. The excretion of melatonin is suspended under bright lights; the start of dim light prompts the recommencement of its excretion. It appears to assume a key part in directing the body's circadian rhythms and has been utilized restoratively to re-entrain irritated circadian rhythms. Exogenic melatonin conduces the production of a phase advance when it is consumed towards the evening [31,32], as its impact is
The symptoms of jetlag
Albeit, vast numbers of signs of jetlag have been related with high-altitude flights, the differing determinants however seem to be the duration of the symptoms. Side effects identified with flight travel generally last under 24 h, though those of jetlag may persevere for a significantly longer period of time. The span of the flight is the primary cause of the severity and period of time that jetlag persists. Passengers who travel over more than 3 or more different time belts are more
Treatment
A number of preventative actions can be taken to diminish the effects of jetlag. Undoubtedly, by sleeping during the flight travelers may curtail the severity of sleep deprivation. The ideal time to do this would be during the hours that correspond to the new destination's nighttime; however, short bouts of rest will also be helpful. Short periods of sleep have the additional advantage of diminishing photic stimulation, also decreasing the depth of sleep one falls into. Using eye masks and
Conclusion
The signs of jetlag consist of feeling tired during the day, impeded awareness and insomnia during the night and disruption of sleeping and waking patterns. Jetlag connected sleep issues were noted to be more common in travelers who passed multiple time belts. The melatonin hormone has a critical part in ascertaining the body's circadian rhythms and has been utilized remedially to re-entrain disturbed circadian rhythms.
Financial disclosure
There is no financial disclosures of the authors.
Author contribution and responsibilities
Cemal Cingi: Planning, literature survey.
Ismet Emrah Emre: Planning, literature survey, language editing.
Nuray Bayar Muluk: Planning, literature survey, writing the manuscript, submission.
Conflicts of interest
Author Cemal Cingi declares that he has no conflict of interest.
Author Ismet Emrah Emre declares that he has no conflict of interest.
Author Nuray Bayar Muluk declares that she has no conflict of interest.
Ethical approval
There is no need to take ethical approval, because this paper is review.
Informed consent
There is no need to take informed consent, because this paper is review.
Acknowledgement
“With exception of data collection, preparation of this paper including design and planning was supported by Continuous Education and Scientific Research Association.” There is no financial support. There is only scientific support.
References (62)
- et al.
Jet lag: therapeutic use of melatonin and possible application of melatoninanalogs
Trav Med Infect Dis
(2008) - et al.
Adapting to phase shifts, I. An experimental model for jet lag and shift work
Physiol Behav
(1996) - et al.
Time zone change and major psychiatric morbidity: the results of a 6-year study in Jerusalem
Compr Psychiatr
(2002) - et al.
Light exposure in the natural environment: relevance to mood and sleepdisorders
Sleep Med
(2007) Circadian genes, rhythms and the biology of mood disorders
Pharmacol Ther
(2007)- et al.
The hypothalamic integrator for circadian rhythms
Trends Neurosci
(2005) - et al.
Interactions of the circadian CLOCK system and the HPA axis
Trends Endocrinol Metab
(2010) - et al.
Psychobiological allostasis: resistance, resilience and vulnerability
Trends Cogn Sci.
(2011) - et al.
Circadian-time sickness: time- of-day cue-conflicts directly affect health
Trends Neurosci
(2016) - et al.
Luminance coding in a circadian pacemaker: the suprachiasmatic nucleus of the rat and the hamster
Brain Res
(1986)
Effect of light and melatonin and other melatonin receptor agonists on human Circadian Physiology
Sleep Med Clin
The basic physiology and pathophysiology of melatonin
Sleep Med Rev
Health in a 24-h society
Lancet
Delayed sleep phase syndrome response to melatonin
Lancet
Bright light, dark and melatonin can promote circadian adaptation in night shift workers
Sleep Med Rev
Improvement of sleep quality in elderly people by controlled-release melatonin
Lancet
Placebo-controlled trial of agomelatine in the treatment of major depressive disorder
Eur Neuropsychopharmacol
Zolpidem reduces the sleep disturbance of jet lag
Sleep Med
Melatonin for the prevention and treatment of jet lag
Cochrane Database Syst Rev
Melatonin efficacy in aviation missions requiring rapid deployment and night operations
Aviat Space Environ Med
Molecular circadian rhythms in central and peripheral clocks in mammals
Chronobiol Int
Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?
Eur J Neurosci
Stability, precision, and near-24-h period of the human circadian pacemaker
Science
Neural regulation of circadian rhythms
Physiol Rev
Differential control of cardiac and sympathetic vasomotor activity from the dorsomedial hypothalamus
Clin Exp Pharmacol Physiol
Functional MT1 and MT2 melatonin receptors in mammals
Endocrine
A clockwork web: circadian timing in brain and periphery, in health and disease
Nat Rev Neurosci
When clocks go bad: neurobehavioural consequences of disrupted circadian timing
PLoS Genet
Disrupted sleep: from molecules to cognition
J Neurosci
Aberrant light directly impairs mood and learning through melanopsin- expressing neurons
Nature
Cited by (20)
Healthy sleep: basic sleep tips
2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second EditionPathophysiology, associations, and consequences of circadian rhythm sleep wake disorders
2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second Edition3D printing of four-in-one oral polypill with multiple release profiles for personalized delivery of caffeine and vitamin B analogues
2021, International Journal of PharmaceuticsCitation Excerpt :However, folic acid supplementation was also associated with an increased risk of advanced colorectal lesions and adenoma multiplicity, highlighting the need for personalized supplementation (Figueiredo et al., 2008). Accordingly, an individual’s lifestyle may strongly affect the supplementation requirement such as for sports athletes (Burke et al., 2019; Guest et al., 2019; Peeling et al., 2018), or frequent travelers (Cingi et al., 2018). Finally, with the benefits of supplements in managing chronic diseases (Cicero et al., 2020; Larussa et al., 2017; Rautiainen et al., 2016; Van der Velden, 2020), it is obvious that pre-existing medical conditions would also contribute to the choice of supplementation.
Association between circadian disruption and diseases: A narrative review
2020, Life SciencesCitation Excerpt :Patients with irregular sleep–wake rhythm disorder are characterized by at least three separate sleep periods across the 24-hour day, while patients with non-24-hour sleep–wake rhythm disorder experience a gradual delay that results in a prolonged period of the sleep–wake rhythm (i.e., lasting longer than 24 h) [10]. Shift-work and jet-lag disorders both result from the misalignment of behavioral cycles with environmental changes due to the inevitable alteration of the sleep–wake phase [5,11]. Moreover, “social jet lag,” which is used to describe the phenomenon where individuals choose different sleep schedules on workdays and leisure days, affects characteristics of the sleep–wake cycle, including total hours, onset latency, and efficiency, especially among those with an evening circadian type [12].
Etiopathogenesis of Circadian Sleep-Wake Rhythm Disorders
2020, Neurological Modulation of Sleep: Mechanisms and Function of Sleep HealthReaction of the endogenous regulatory mechanisms to early weekday wakeups: a review of its popular explanations in light of model-based simulations
2023, Frontiers in Network Physiology