Elsevier

Toxicon

Volume 52, Issue 8, 15 December 2008, Pages 960-963
Toxicon

Short communication
The differences of platelet response to snake venoms: A comparative study of children and adults

https://doi.org/10.1016/j.toxicon.2008.09.007Get rights and content

Abstract

Platelets play a vital role in the coagulation, yet the potential for differences in platelet function, between adults and children, remains underexplored. This is despite the age-related variation in haemostatic proteins, that is encompassed by the term Developmental Haemostasis. Hemotoxins found in the venoms of Australian snakes mimic human blood coagulation factors. The effects of Australian snake venoms on platelets, as well as the possible differential response in adults and children were subject of this study.

Cited by (2)

  • Red-bellied black snake (Pseudechis porphyriacus) envenomation in the dog: Diagnosis and treatment of nine cases

    2016, Toxicon
    Citation Excerpt :

    This difference, from a recent human case series that did not report any evidence of RBBS venom-induced prothrombin activation (Churchman et al., 2010) might reflect species and developmental haematological differences. Indeed such age-related differences in human haematological responses to Australian snake venoms have been previously documented for coastal taipan (Oxyuranus scutellatus) and common tiger snake (N. scutatus) venoms (Kern et al., 2008). RBBS venom contains a potent direct haemolysin that induces extensive haemolysis in vitro (Doery and Pearson, 1961) and in vivo (Martin, 1893).

  • Children and Snakebite: Snake Venom Effects on Adult and Paediatric Plasma

    2023, Toxins
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