Original Contributions: Case ReportsKidney transplantationNephrogenic Adenoma Complicating Renal Transplantation: A Case Report and Discussion
Section snippets
Case Report
Mr RB was a 69-year-old man who underwent cadaveric renal transplantation for end-stage kidney disease secondary to antibiotic induced interstitial nephritis, after 3 years of hemodialysis. Graft cold ischemia time was 9 hours, with 30 minutes of warm ischemia time. One HLA mismatch and no donor-specific antibodies were present. Donor and recipient cytomegalovirus statuses were negative and positive, respectively. Immediate graft function was observed, and immune suppression was maintained with
Discussion
Adenomatous growths with a marked histologic similarity to renal tubules were first characterized by Davis in 1949, and the term “nephrogenic adenoma” (NA) was introduced by Friedman and Kuhlenbeck the following year [1], [2]. Despite having long been considered to be an uncommon lesion, case series in the renal transplant (RT) recipient population have demonstrated a prevalence within this group of 0.53%–4.84% [3], [4]. As such, NA can not be considered to be rare among RT recipients.
Conclusion
The case reported here highlights the capacity for NA to cause significant morbidity despite best management with cystoscopic resection. Further work is required to fully elucidate the pathogenesis of this lesion and to identify strategies for the management of persistent UTI and recurrence in NA patients, particularly in the RT population.
Acknowledgments
Thank you to the staff in the departments of Nephrology and Anatomical Pathology at St. Vincent's Hospital Melbourne for facilitating this work.
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