Advances in TransplantationLung TransplantationOutcomes Following Extracorporeal Photopheresis for Chronic Lung Allograft Dysfunction Following Lung Transplantation: A Single-Center Experience
Section snippets
Methods
We performed a retrospective descriptive audit of all LTx patients who underwent ECP treatment from 2013 until June 2018.
Demographics
Twelve patients underwent ECP as rescue therapy for CLAD from November 2013 to June 2018. Patient demographics are described in Table 1. Baseline immunosuppression and previous therapies for CLAD are described in Table 2. All patients achieved therapeutic levels of immunosuppression as per our hospital protocol. All patients, except 1, were taking azithromycin at time of ECP commencement (drug intolerance, nausea).
Seventeen percent had rejection evident on transbronchial biopsy International
Discussion and Conclusion
Despite being introduced as late rescue therapy, there did appear to be an efficacy signal, with 67% of CLAD patients demonstrating a reduction in the rate of declining FEV1 from 9.0 to 1.4 mL/day. Morrell et al reported a similar single-center experience of patients receiving ECP for BOS and found a mean difference in rate of decline of 87.1 mL/month [15]. Pecoraro et al reported a single-center experience of 54 patients with BOS, 15 of whom received ECP therapy. Patients who received ECP had
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