Short CommunicationActivin A as a novel biomarker of equine inflammatory abdominal disease: Preliminary findings⋆
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Conflict of interest statement
E. Sorich was previously employed by ARL Pathology Pty Ltd., which supplied the ELISA kits used to detect SAA. None of the other authors of this paper has any financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.
Acknowledgements
The authors are grateful to ARL Pathology Pty Ltd. for providing the SAA ELISA kits. They also thank Mr. Garry Anderson for his advice on the statistical analysis.
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Plasma activin A concentrations during late gestation in Thoroughbred mares with abnormal pregnancies
2023, Journal of Equine Veterinary ScienceCitation Excerpt :This small difference in activin A concentration between groups might be related to the treatment effect or clinical status of the mares. Moreover, an increase in activin A indicates inflammation in not only uterus-placental tissue, but also in other parts of the body [8], and an acute increase in activin A concentrations has been reported in various clinical conditions, including septicemia [25]. The peak of activin A has been reported to appear on the day of parturition in Thoroughbred mares [21], consistent with a study in human pregnancy that showed a large amount of activin A secretion from the placenta into the maternal circulation during active labor [28].
Plasma Activin A and Decorin in Exercised Purebred Arabian Horses – Preliminary Study
2021, Journal of Equine Veterinary ScienceCitation Excerpt :Lifestyle appears to influence plasma activin levels, as activin mRNA expression and the plasma activin concentration are enhanced in physically active humans and rats [5,6]. Up to now, studies of activin A in horses have shown that it is a specific marker of inflammation and acute abdominal and lung diseases [7–9]. On the other hand, glucocorticoids, which can be secreted in response to inflammation or exercise-induced stress, strongly reduce activin A production [10,11] and vice versa, activin A inhibits cortisol secretion from the adrenal cortex [12].
Effects of advanced age and pituitary pars intermedia dysfunction on components of the acute phase reaction in horses
2020, Domestic Animal EndocrinologyCitation Excerpt :In the literature, there is no data regarding the assessment of the ACT concentration in horses. Activin A, a member of the transforming growth factor-β subfamily, is increased in the case of inflammatory or strangulating lesions in the abdominal cavity and in cases of equine grass sickness [60,61]. Procalcitonin is increased in the cerebral spinal fluid in humans with neurodegenerative diseases, whereas its increase in peripheral blood is correlated with bacterial infections of the central nervous system [62].
Effects of equine metabolic syndrome on inflammation and acute-phase markers in horses
2020, Domestic Animal EndocrinologyCitation Excerpt :These data suggest that these moderately sensitive acute-phase proteins may not be suitable markers of low-grade inflammation in horses with EMS. Activin A has been recently used in horses as a marker of inflammatory or strangulating lesions in the abdominal cavity and in equine grass sickness [64,65]. In response to LPS in sheep, there is a more rapid increase in the concentration of activin A than in classic proinflammatory cytokines, specifically IL-6 and TNF-α [66].
A review on equine colic: Etiology, differential diagnosis, therapy, and prevention
2023, German Journal of Veterinary ResearchBiomarkers of Intestinal Injury in Colic
2023, Animals
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