Validity of self-reported influenza and pneumococcal vaccination status among a cohort of hospitalized elderly inpatients
Introduction
Influenza vaccine and 23-valent pneumococcal vaccine (23vPPV) have been recommended for elderly persons in a number of countries for some time [1], [2]. In Australia, these vaccines have been funded nationally since 1998 and 2005, respectively [3], while in the state of Victoria, 23vPPV has been funded since 1998 [4]. Evaluation of the impact of these programs on coverage requires accurate measurement of vaccination status. Self-reported vaccination status is frequently used in public health program evaluation, as well as in clinical research and clinical practice as a marker of true vaccination status. There are in fact few practical alternatives where no register of adult vaccinations exists. If self-reported status 23vPPV and influenza vaccination status are to be used to guide practice their validity must be established.
To our knowledge, six studies examining the validity of self-reported 23vPPV and/or influenza vaccination status have been previously published [5], [6], [7], [8], [9], [10], in addition to one appearing as a conference proceeding [11]. These were based on relatively small numbers of subjects (mean 379, range 135–820), have some data limitations, conflicting results and only two [8], [10] were conducted outside North America. Estimates from earlier studies could have been affected in either direction by poor response rates (as low as 59%) [7], response bias [6] or selection bias [11]. The latest three studies were small (n = 135–354) [8], [9], [10]. None have adjusted estimates for potential confounders except for Zimmerman et al. (restriction of analyses to examine effects of age and vaccination within physicians’ offices) [7] and Mac Donald et al. (time since vaccination with 23vPPV) [6]. Further exploration of the validity of self-reported 23vPPV and influenza vaccination status as an evaluation tool is warranted. Such information can inform the assessment process for the current Australian program in persons aged ≥65 years, as well as similar programs in other countries, and clinicians vaccinating individuals.
As part of a large case–cohort study examining vaccine effectiveness, we undertook to quantify the validity of self-reported vaccination status for 23vPPV and influenza vaccine as an indicator of true vaccination status.
Section snippets
Study design
The case–cohort design is a variant of the case–control study where the comparison group is selected to represent the entire population (the cohort), and is a random sample (independent of case characteristics) of all persons in the population from which the cases are drawn, rather than only those who are unaffected (controls). Hence some cases may also be sampled in the cohort [12]. Unlike a case–control study, no rare disease assumption is required, and the risk ratio (RR) is directly
Description of eligible subjects and data availability
Of 4887 selected subjects, more consented to contacting their vaccine providers to confirm vaccination status (4166/4887, 85%) than to undertaking a questionnaire including self-reported vaccination status (3534/4887, 72%) (Fig. 1). About 2404/3534 (68%) consenting subjects provided a “yes” or “no” response for their 23vPPV status for the preceding 5 years and 3250/3534 (92%) for influenza vaccination status for the previous year. Providers responded to requests for information on vaccination
Influenza vaccine
Estimates from this study of the validity of self-reported influenza vaccination status are consistent with the range provided by previous smaller studies (Table 4) [5], [6], [7], [8], [10]. They remained consistent when the study population was no longer restricted to those providing self-report data in person, first hospital presentations, or where those with “don’t know” responses were assumed to be unvaccinated. Although self-report was highly sensitive, with almost all truly vaccinated
Acknowledgements
The study was approved by the Human Research Ethics Committee, Melbourne Health (ref 2000.022). It was jointly funded by the Victorian Government Department of Human Services and the National Health and Medical Research Council (grant number 146500). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or preparation or approval of the report. This study was supported by research assistants responsible for data collection: Anne-Marie Woods,
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