Short communicationNo increase in the expression of key unfolded protein response genes in HCV genotype 3 patients with severe steatosis
Section snippets
Acknowledgements
We thank A/Prof John Slavin and A/Prof Richard Williams from the St. Vincent's Hospital Department of Pathology for assistance in histological analysis of tissues.
References (34)
- et al.
An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group
Hepatology
(1996) - et al.
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Am. J. Gastroenterol.
(1999) - et al.
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core
J. Hepatol.
(2007) - et al.
ATF4-dependent transcription mediates signaling of amino acid limitation
Trends Endocrinol. Metab.
(2009) - et al.
HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma
Biochem. Biophys. Res. Commun.
(2007) - et al.
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation
Virology
(2009) - et al.
Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis
J. Hepatol.
(2008) - et al.
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis
Gastroenterology
(2006) - et al.
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
Gastroenterology
(2008) - et al.
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
J. Hepatol.
(2000)
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
Dev. Cell
(2008)
Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
Hepatology
(2001)
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C
J. Pathol.
(2010)
Experimental models for hepatitis C viral infection
Hepatology
(2009)
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
Hepatology
(2004)
Hepatitis C virus envelope proteins regulate CHOP via induction of the unfolded protein response
FASEB J.
(2005)
Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
BMC Genomics
(2008)
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