Mapping of functional activity in brain with 18F-fluoro-deoxyglucose**
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2022, PET ClinicsCitation Excerpt :The regions of image are labeled with their respective class based on a pattern recognition algorithm by using predetermined features.22 The details of medical image segmentation algorithms are available and written elsewhere.23–26 An international standard RECIST 1.1 criterion with the help of anatomic imaging is used commonly in the assessment of treatment responses for solid tumors.
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2019, PET ClinicsCitation Excerpt :Fluorodeoxyglucose (FDG)-PET imaging was first conceived in the early 1970s by researchers at the University of Pennsylvania as a means of noninvasively measuring brain’s function and metabolism.5 Initially, FDG-PET was predominantly used for the early detection and assessment of various neurologic disorders.6,7 Soon thereafter, the application of this imaging modality was expanded as FDG-PET became a prominent technique for diagnosis, staging, treatment response monitoring, and prognosis of different malignancies.8
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2015, PET ClinicsCitation Excerpt :Compartmental modeling establishes the link between the functional image and physiologic parameters of glucose metabolism. In this model, the behavior of FDG is mathematically modeled using a certain number of compartments representing various stages of FDG metabolism.17–21 The dynamic trend of change in FDG concentration follows a 3-compartment tracer kinetic model consisting of the process of transportation and phosphorylation of FDG (Fig. 3).
Novel Quantitative Techniques for Assessing Regional and Global Function and Structure Based on Modern Imaging Modalities: Implications for Normal Variation, Aging and Diseased States
2007, Seminars in Nuclear MedicineCitation Excerpt :This modeling describes the behavior of FDG in cells mathematically, with a certain assumed number of compartments, each of which represents a distinct physical and/or biochemical stage in the behavior of the tracer. Such models were developed to describe the kinetics of the glucose analogs [14C]-deoxyglucose and FDG in the pioneering work on tracer kinetic modeling.1,2,5-7 FDG is transported from the blood pool across the cell membrane by glucose transporters, where it is phosphorylated by the enzyme hexokinase.
Clinical and Research Applications of Quantitative PET Imaging
2007, PET ClinicsCitation Excerpt :Quantitative metabolic rate assessment by kinetic modeling can measure FDG metabolism and also yield individual rate constants and thereby provide insight into the various components of glucose metabolism such as transport and phosphorylation. Compartmental modeling describes the behavior of FDG in cells mathematically and was developed to describe the kinetics of the glucose analogs [14C]-deoxyglucose and FDG in the pioneering work on tracer kinetic modeling [1,2,4–6]. The tracer kinetic modeling of FDG is based on a standard three-compartment kinetic model (Fig. 1), with two tissue compartments and a single arterial input function.
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Supported in part by USPHS Grant 14867-02.