Elsevier

The Lancet

Volume 314, Issue 8149, 3 November 1979, Pages 931-933
The Lancet

MODULATION OF PLASMA 1,25-DIHYDROXYVITAMIN D IN MAN BY STIMULATION AND SUPPRESSION TESTS

https://doi.org/10.1016/S0140-6736(79)92624-2Get rights and content

Abstract

In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) levels by 80% (peak 8-40 h after infusion) without producing any significant change in plasma calcium, phosphate, or magnesium. An oral calcium load suppressed plasma 1,25-(OH)2D to 63% of control values within 48-72 h. These responses will be useful in the diagnosis and management of disturbances of calcium and mineral metabolism in which vitamin D metabolism is abnormal.

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