Sex Differences and Olfactory Function

Kimberley P. Good; Lili Kopala

doi:10.1017/CBO9780511543623.012

10 - Sex Differences and Olfactory Function

from Section II - Social Functioning: Role of Evolution, Genetics and Gender

Published online by Cambridge University Press: 17 August 2009

Kimberley P. Good and

Edited by

David Castle and

Foreword by

Warrick J. Brewer: Affiliation:
Mental Health Research Institute of Victoria, Melbourne
David Castle: Affiliation:
University of Melbourne
Christos Pantelis: Affiliation:
University of Melbourne

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Summary

Introduction

In the early 1980s, in conjunction with the National Geographic Magazine, Wysocki and Gilbert set out on an ambitious quest. About 10.5 million ‘scratch and sniff’ surveys were distributed with the magazine in the hope of collecting population-based data on olfactory function. Over 1.4 million completed surveys were returned (Wysocki & Gilbert, 1989). Although limited in its scope, the data served to highlight a number of interesting points. Among those reported was the observation that women outperformed men on all measured aspects of olfactory ability. Moreover, the findings suggested that sex differences in olfactory perception were not uniform across different odorants. Although sex differences in olfactory sensitivity have been anecdotally known for centuries, the data derived from this investigation provided further insight into some of the diverse aspects of olfactory functioning that are differentiated between the two sexes. This monumental study served to spur on subsequent olfactory research, particularly in the realm of sex differences.

This chapter reviews the literature on sex differences in olfactory ability and describes the current state of knowledge on this subject. Moreover, some methodological shortcomings in published reports are outlined. Finally, some hypotheses are offered in order to explain the male/female difference in olfactory function.

Males and females differ in their ability to process odorants

Olfactory findings

Sex differences in olfactory function have been observed on virtually all olfactory measures examined.

Keywords

functional imaging menstrual cycle olfactory function sex differences socially irrelevant stimuli socially relevant odours

Type: Chapter
Information: Olfaction and the Brain , pp. 183 - 202

DOI: https://doi.org/10.1017/CBO9780511543623.012 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2006

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References

Amoore, J. & Venstrom, D. (1966) Sensory analysis of odor qualities in relation to age, sex, or smoking. J Food Sci, 31, 118–28.Google Scholar

Amoore, J., Popplewell, J. & Whissell-Buechy, D. (1975) Sensitivity of women to musk odor: no menstrual variation. J Chem Ecol, 1, 291–7.Google Scholar

Balogh, R. & Porter, R. (1986) Olfactory preference resulting from mere exposure in human neonates. Inf Behav Dev, 9, 395–401.Google Scholar

Barber, C. (1997) Olfactory acuity as a function of age and gender: a comparison of African and American samples. Int J Aging Hum Dev, 44, 317–34.Google Scholar

Baxter, L., Saykin, A., Flashman, L., et al. (2003) Sex differences in semantic language processing: a functional MRI study. Brain Lang, 84, 264–72.Google Scholar

Becker, E., Hummel, T., Piel, E., et al. (1993) Olfactory event-related potentials in psychosis-prone subjects. Int J Psychophysiol, 15, 51–8.Google Scholar

Bengtsson, S., Berglund, H., Gulyas, B., et al. (2001) Brain activation during odour perception in males and females. Chem Senses, 12, 2027–33.Google Scholar

Brand, G. & Millot, J. (2001) Sex differences in human olfaction: between evidence and enigma. Quart J Exp Psychol, 54B, 259–70.Google Scholar

Bremner, E., Mainland, J., Khan, R., et al. (2003) The prevalence of androstenone anosmia. Chem Senses, 28, 423–32.Google Scholar

Cantoni, P., Hudson, R., Distel, H., et al. (1999) Changes in olfactory perception and dietary habits in the course of pregnancy: a questionnaire study. Chem Senses, 24, 58.Google Scholar

Caruso, S., Grillo, C., Agnello, C., et al. (2001) A prospective study evidencing rhinomanometric and olfactometric outcomes in women taking oral contraceptives. Hum Reprod, 16, 2288–94.Google Scholar

Choudhury, E., Moberg, P. & Doty, R. (2003) Influences of age and sex on a microencapsulated odor memory test. Chem Senses, 28, 799–805.Google Scholar

Corwin, J., Loury, M. & Gilbert, A. (1995) Workplace, age and sex as mediators of olfactory function: Data from the National Geographic Smell Survey. J Gerontol, 50, 179–86.Google Scholar

Deems, D., Doty, R., Settle, G., et al. (1991) Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg, 117, 519–28.CrossRef Google Scholar

Dempsey, R. & Stevenson, R. (2002) Gender differences in the retention of Swahili names for unfamiliar odors. Chem Senses, 27, 681–9.Google Scholar

Dorries, K., Schmidt, H., Beauchamp, G., et al. (1989) Changes in sensitivity to the odor androstenone during adolescence. Dev Psychobiol, 22, 423–35.Google Scholar

Doty, R. (1986) Reproductive, endocrine influences upon olfactory perception: a current perspective. J Chem Ecol, 12, 497–511.Google Scholar

Doty, R. (1991) Olfactory System. In Smell and Taste in Health and Disease (ed Getchell, T. V.), pp. 175–203. New York: Raven Press.

Doty, R. (1995) The Smell Identification Test Administration Manual (3rd edn). Haddon Heights, New Jersey: Sensonics, Inc.

Doty, R. (2003) Mammalian pheromones: fact or fantasy? In Handbook of Olfaction and Gustation (ed R. Doty), pp. 345–83. New York: Marcel Dekker, Inc.

Doty, R., Brugger, W., Jurs, P., et al. (1978) Intranasal trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and normal humans. Physiol Beh, 20, 175–85.Google Scholar

Doty, R., Snyder, P., Huggins, G., et al. (1981) Endocrine, cardiovascular and psychological correlates of olfactory sensitivity changes during the human menstrual cycle. J Comp Physiol Psychology, 96, 46–80.Google Scholar

Doty, R., Shaman, P. & Dann, M. (1984) Development of the University of Pennsylvania Smell Test: standardized microencapsulated test for olfactory function. Physiol Beh, 32, 489–502.Google Scholar

Doty, R., Applebaum, S., Zusho, H., et al. (1985) Sex differences in odor identification ability: a cross cultural analysis. Neuropsychologia, 23, 667–72.Google Scholar

Engen, T. & Ross, B. (1973) Long-term memory of odours with and without verbal descriptions. J Exp Psychology, 110, 221–7.Google Scholar

Evans, W., Cui, L. & Starr, A. (1995) Olfactory event-related potentials in normal human subjects: effects of age and gender. Electroencephal Clin Neurophysiol, 95, 293–301.Google Scholar

Gangestad, S. & Thornhill, R. (1998) Menstrual cycle variation in women's preferences for the scent of symmetrical men. Proc R Soc Lon Biol Sci, 265, 927–33.Google Scholar

Goldstein, J., Seidman, L., Horton, N., et al. (2001) Normal sexual dimorphisms of the adult human brain assessed by in-vivo magnetic resonance imaging. Cerebral Cortex, 11, 490–7.Google Scholar

Gower, D., Bird, S., Sharma, P., et al. (1985) Axillary 5α-androst-16-en-3-one in men and women: relationship with olfactory acuity to odorous 16-androstenes. Experientia, 41, 1134–6.Google Scholar

Grammer, K. (1993) 5-α-androst-16en-3α-on: a male hormone: A brief report. Ethol Sociobiol, 14, 201–8.Google Scholar

Grillo, C., Mantia, I., Triolo, C., et al. (2001) Rhinomanometric and olfactometric variations throughout the menstrual cycle. Ann Otol Rhinol Laryngol, 110, 785–9.Google Scholar

Haeggstrom, A., Ostberg, B., Stjerna, P., et al. (2000) Nasal mucosal swelling and reactivity during a menstrual cycle. J Oto-rhino-laryngol, 62, 39–42.Google Scholar

Herz, R. & Engen, T. (1996) Odor memory: review and analysis. Psychon Bull Rev, 3, 300–13.Google Scholar

Herz, R. & Cahill, E. (1997) Differential use of sensory information in sexual behavior as a function of gender. Hum Nature, 8, 275–86.Google Scholar

Herz, R. & Clef, J. (2001) The influence of verbal labelling on the perception of odors: Evidence for olfactory illusions?Percep, 30, 381–91.Google Scholar

Hornung, D. & Leopold, D. (1999) Relationship between uninasal anatomy and uninasal olfactory ability. Arch Otolaryngol Head Neck Surg, 125, 53–8.Google Scholar

Hughes, L., McAsey, M., Donothan, C., et al. (2002) Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studies. Climateric, 5, 140–50.Google Scholar

Hulshoff Pol, H., Hijman, R., Baare, W., et al. (2000) Odor discrimination and task duration in young and older adults. Chem Senses, 25, 461–4.Google Scholar

Hummel, T., Gollisch, R., Wildt, G., et al. (1991) Changes in olfactory perception during the menstrual cycle. Experientia, 47, 712–15.Google Scholar

Jones-Gotman, M. & Zatorre, R. (1988) Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia, 26, 387–400.Google Scholar

Karlson, P. & Luscher, M. (1959) 'Pheromones': A new term for a class of biologically active substances. Nature, 183, 55–56.Google Scholar

Kirk-Smith, M. & Booth, D. (1980) Effect of androstenone on choice of location in others' presence. InOlfaction and Taste VII (ed H. Van der Starre), pp. 397–400. London: IRL Press.Google Scholar

Koelega, H. (1994) Sex differences in olfactory sensitivity and the problem of the generality of smell acuity. Percept Mot Skills, 78, 203–13.Google Scholar

Koelega, H. & Koster, E. (1974) Some experiments on sex differences in odor perception. Ann NY Acad Sci, 237, 234–46.Google Scholar

Kolble, N., Hummel, T., Mering, R., et al. (2001) Gustatory and olfactory function in the first trimester of pregnancy. Eur J Obst Gyn Reprod Biol, 99, 179–83.Google Scholar

Kopala, L., Good, K. & Honer, W. (1995) Olfactory identification ability in pre- and post-menopausal women with schizophrenia. Biol Psychiatry, 38, 57–63.Google Scholar

Laine-Alava, M. & Minkkinen, U. (1999) Should a history of nasal symptoms be considered when estimating nasal patency?Angle Orthod, 69, 126–32.Google Scholar

Larsson, M., Finkel, D. & Pedersen, N. (2000) Odor identification: Influences of age, gender, cognition and personality. J Geront, 55B, 304–10.Google Scholar

Larsson, M., Lovden, M. & Nilsson, L. (2003) Sex differences in recollective experience for olfactory and verbal information. Acta Psychol, 112, 89–103.Google Scholar

Laska, M., Koch, B., Heid, B., et al. (1996) Failure to demonstrate systematic changes in olfactory perception in the course of pregnancy: a longitudinal study. Chem Senses, 21, 567–71.Google Scholar

Magnen, J. (1952) Les phenomenes olfacto-sexuels chez l'homme. Arch Sci Physiol, 6, 125–60.Google Scholar

Lehrner, J. (1993) Gender differences in long-term odor recognition memory: verbal versus sensory influences on the consistency of label use. Chem Senses, 18, 17–26.CrossRef Google Scholar

Levy, L., Henkin, R., Hutter, A., et al. (1997) Functional MRI of human olfaction. J Comp Assist Tomog, 21, 849–56.Google Scholar

Mair, R., Bouffard, J., Engen, T., et al. (1978) Olfactory sensitivity during the menstrual cycle. Sens Proc, 2, 90–8.Google Scholar

Makin, J. & Porter, R. (1989) Attractiveness of lactating females breast odors to neonates. Child Dev, 60, 803–10.Google Scholar

Mallet, P. & Schaal, B. (1998) Rating and recognition of peers' personal odors by 9-year old children: An exploratory study. J Gen Psychol, 125, 47–64.Google Scholar

McClintock, M. (1971) Menstrual synchrony and suppression. Nature, 229, 244–5.Google Scholar

McClintock, M. (1984) Estrous synchrony: modulation of ovarian cycle length by female pheromones. Physiol Beh, 32, 701–5.Google Scholar

McGlone, J. (1977) Sex differences in the cerebral organization of verbal function in patients with unilateral brain lesions. Brain, 100, 775–93.Google Scholar

Messe, L., Chisena, P. & Shipley, R. (1968) A sex difference in the recognition level of words. Psychonom Sci, 11, 131–2.Google Scholar

Morgan, C., Covington, J., Geisler, M., et al. (1997) Olfactory event-related potentials: older males demonstrate greater deficits. Electroenceph Clin Neurophysiol, 104, 351–8.Google Scholar

Navarrete-Palacios, E., Hudson, R., Reyes-Guerrero, G., et al. (2003) Lower olfactory threshold during ovulatory phase of the menstrual cycle. Biol Psychiatry, 63, 269–79.Google Scholar

Nopoulos, P., Flaum, M., O'Leary, D., et al. (2000) Sexual dimorphism in the human brain: evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry Res: Neuroimaging Section, 98, 1–13.Google Scholar

Nordin, S., Nyroos, M., Maunuksela, E., et al. (2002) Applicability of the Scandinavian Odor Identification Test: A Finnish-Swedish comparison. Acta Otolaryng, 122, 294–7.Google Scholar

Oberg, C., Larsson, M. & Backman, L. (2002) Differential sex effects in olfactory functioning: the role of verbal processing. J Int Neuropsychological Soc, 8, 691–8.Google Scholar

Paulsson, B., Gredmark, T., Burian, P., et al. (1997) Nasal mucosal congestion during the menstrual cycle. J Laryngol Otol, 111, 337–9.Google Scholar

Pause, B., Rogalski, K., Sojka, B., et al. (1999) Sensitivity to androstenone in female subjects is associated with an altered brain response to male body odor. Physiol Beh, 68, 129–37.Google Scholar

Pfaff, D. & Pfaffmann, C. (1969) Olfactory and hormonal influences on the basal forebrain of the male rat. Brain Res, 15, 137–56.Google Scholar

Philpott, C., El-Alami, M. & Murty, G. (2004) The effect of the steroid sex hormones on the nasal airway during the normal menstrual cycle. Clin Otolaryngol, 29, 138–42.Google Scholar

Purdon, S., Klein, S. & Flor-Henry, P. (2001) Menstrual effects on asymmetrical olfactory acuity. J Int Neuropsychological Soc, 7, 703–9.Google Scholar

Rabin, M. & Cain, W. (1984) Odor recognition: familiarity, identifiability, and encoding consistency. J Exp Psychol Learning Memory, 316–25.Google Scholar

Savic, I., Berglund, H., Gulyas, B., et al. (2001) Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron, 31, 661–8.Google Scholar

Shaywitz, B., Shaywitz, S., Pugh, K., et al. (1995) Sex differences in the functional organization of the brain for language. Nature, 373, 561–2.Google Scholar

Shaywitz, S., Shaywitz, B., Pugh, K., et al. (1999) Effect of estrogen on brain activation patterns in post menopausal women during working memory tasks. J Am Med Assoc, 281, 1197–202.Google Scholar

Sherwin, B. (1994) Estrogenic effects on memory in women. Ann NY Acad Sci, 743, 213–30.Google Scholar

Shima, N., Yamaguchi, Y. & Yuri, K. (2003) Distribution of estrogen receptor beta mRNA-containing cells in ovariectomized and estrogen-treated female rat brain. Anatom Sci Int, 78, 85–97.Google Scholar

Ship, J. & Weiffenbach, J. (1993) Age, gender, medical treatment and medication effects on smell identification. J Gerontol, 48, M26–M32.Google Scholar

Ship, J., Pearson, J., Cruise, L., et al. (1996) Longitudinal changes in smell identification. J Gerontol, 51A, M86–M91.Google Scholar

Sobel, N., Prabhakaran, V., Desmond, J., et al. (1997) A method for functional magnetic resonance imaging of olfaction. J Neurosci Meth, 78, 115–23.Google Scholar

Stern, K. & McClintock, M. (1998) Regulation of ovulation by human pheromones. Nature, 392, 177–9.Google Scholar

Stevenson, R. & Repacholi, B. (2003) Age-related changes in children's hedonic response to male body odor. Dev Psychol, 39, 670–9.Google Scholar

Swaab, D. & Fliers, E. (1985) A sexually dimorphic nucleus in the human brain. Science, 228, 1112–15.Google Scholar

Trevathan, W., Burleson, N. & Gregory, L. (1993) No evidence for menstrual synchrony in lesbian couples. Psychoneuroendocrinol, 18, 425–31.Google Scholar

Verron, H. & Gaultier, G. (1976) Processus olfactifs et structures relationnelles. Psychologie Francaise, 21, 205–9.Google Scholar

Vierling, J. & Rock, J. (1967) Variations in olfactory sensitivity to Exaltolide during the menstrual cycle. J App Physiol, 22, 311–15.Google Scholar

Wallach, M. & Kogan, N. (1959) Sex differences and judgment processes. J Pers, 27, 555–64.Google Scholar

Wedekind, C. & Furi, S. (1997) Body odour preferences in men and women: do they aim for specific MHC combinations or simply heterozygosity. Proc R Soc Lon, 264, 1471–9.Google Scholar

Weller, A. & Weller, L. (1992) Menstrual synchrony in female couples. Psychoneuroendocrinol, 17, 171–7.Google Scholar

Weller, A. & Weller, L. (1997) Menstrual synchrony under optimal conditions: Bedouin families. J Comp Psychol, 111, 143–51.Google Scholar

Weller, A. & Weller, L. (1998) Prolonged and very intensive contact may not be conducive to menstrual synchrony. Psychoneuroendocrinol, 23, 19–32.Google Scholar

Weller, L. & Weller, A., Koresh-Kamin, H., et al. (1999) Menstrual synchrony in a sample of working women. Psychoneuroendocrinol, 24, 449–59.Google Scholar

Wysocki, C. & Gilbert, A. (1989) National Geographic Smell Survey. Ann NY Acad Sci, 561, 12–28.Google Scholar

Yousem, D., Maldjian, J., Siddiqi, F., et al. (1999) Gender effect on odor-stimulated functional magnetic resonance imaging. Brain Res, 818, 480–7.Google Scholar

Zatorre, R., Jones-Gotman, M., Evans, A., et al. (1992) Functional localization and lateralization of human olfactory cortex. Nature, 360, 339–40.Google Scholar

Zhang, J., Cai, W., Zhou, D., et al. (2002) Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats. Brain Res, 925, 73–80.Google Scholar

Zhou, J., Hofman, M., Gooren, L., et al. (1995) A sex difference in the human brain and its relation to transsexuality. Nature, 378, 68–70.Google Scholar

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10 - Sex Differences and Olfactory Function

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