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17 - Cell Death in the Inner Ear

from Part II - Cell Death in Tissues and Organs

Published online by Cambridge University Press:  07 September 2011

Douglas R. Green
Affiliation:
St. Jude Children's Research Hospital, Memphis, Tennessee
Lisa L. Cunningham
Affiliation:
National Institutes of Health, MD, USA
Justin Tan
Affiliation:
The Bionic Ear Institute, Australia
John C. Reed
Affiliation:
Sanford-Burnham Medical Research Institute, La Jolla, California
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Summary

The inner ear transduces sound energy and head motion into neural impulses. These signals are detected by six sensory patches in the fluid-filled spaces of the inner ear. The snail-shaped cochlea detects sound, whereas the vestibular system serves balance and gravity-detection functions. All six sensory patches in the inner ear use mechanosensory hair cells to transduce fluid motion signals into neurotransmitter release. These sensory cells are sensitive to death from noise trauma, aging, and certain therapeutic drugs. Hair cells in nonmammalian vertebrates are regenerated after they die, resulting in functional recovery of hearing and balance. In contrast, mammalian sensory hair cells are not regenerated, and their loss results in permanent hearing and/or balance disorders. Cochlear hair cells make synaptic connections with spiral ganglion neurons. Spiral ganglion neurons are bipolar cells with dendrites that synapse with the basal surfaces of hair cells and axons that comprise the eighth cranial nerve. Hair cells provide trophic support to spiral ganglion neurons. Therefore, death of hair cells is often followed by spiral ganglion neuron degeneration. Hearing loss is the most common sensory impairment in humans and is the sixth most common chronic health problem in the United States. This chapter addresses apoptotic death of sensory hair cells in response to ototoxic drugs and the subsequent death of spiral ganglion neurons (SGNs).

Type
Chapter
Information
Apoptosis
Physiology and Pathology
, pp. 182 - 193
Publisher: Cambridge University Press
Print publication year: 2011

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References

Adams, P, Hendershot, G, Marano, M (1999) Current Estimates from the National Health Interview Survey, 1996. Hyattsville, MD: National Center for Health Statistics.
Alam, SA, Robinson, BK, Huang, J, Green, SH (2007) Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells. J Comp Neurol 503:832–52.
Ashmore, J (2008) Cochlear outer hair cell motility. Physiol Rev 88:173–210.
Bagger-Sjoback, D, Wersall, J (1978) Gentamicin-induced mitochondrial damage in inner ear sensory cells of the lizard Calotes versicolor. Acta Otolaryngol 86:35–51.
Barbe, MF, Tytell, M, Gower, DJ, Welch, WJ (1988) Hyperthermia protects against light damage in the rat retina. Science 241:1817–20.
Beere, HM, Wolf, BB, Cain, K, Mosser, DD, Mahboubi, A, Kuwana, T, Tailor, P, Morimoto, RI, Cohen, GM, Green, DR (2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2:469–75.
Bhakar, AL, Howell, JL, Paul, CE, Salehi, AH, Becker, EB, Said, F, Bonni, A, Barker, PA (2003) Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J Neurosci 23:11373–81.
Bruey, JM, Ducasse, C, Bonniaud, P, Ravagnan, L, Susin, SA, Diaz-Latoud, C, Gurbuxani, S, Arrigo, AP, Kroemer, G, Solary, E, Garrido, C (2000) Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2:645–52.
Campbell, KC, Meech, RP, Klemens, JJ, Gerberi, MT, Dyrstad, SS, Larsen, DL, Mitchell, DL, El-Azizi, M, Verhulst, SJ, Hughes, LF (2007) Prevention of noise- and drug-induced hearing loss with D-methionine. Hear Res 226:92–103.
Cheng, AG, Cunningham, LL, Rubel, EW (2003) Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation. J Assoc Res Otolaryngol 4:91–105.
Cheng, AG, Cunningham, LL, Rubel, EW (2005) Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg 13:343–8.
Chopp, M, Chen, H, Ho, KL, Dereski, MO, Brown, E, Hetzel, FW, Welch, KM (1989) Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat. Neurology 39:1396–8.
Clerici, WJ, Hensley, K, DiMartino, DL, Butterfield, DA (1996) Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 98:116–24.
Clough, RL, Sud, R, Davis-Silberman, N, Hertzano, R, Avraham, KB, Holley, M, Dawson, SJ (2004) Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochem Biophys Res Commun 324:372–81.
Conlon, BJ, Perry, BP, Smith, DW (1998) Attenuation of neomycin ototoxicity by iron chelation. Laryngoscope 108:284–7.
Coradini, PP, Cigana, L, Selistre, SG, Rosito, LS, Brunetto, AL (2007) Ototoxicity from cisplatin therapy in childhood cancer. J Pediatr Hematol Oncol 29:355–60.
Corwin, JT, Cotanche, DA (1988) Regeneration of sensory hair cells after acoustic trauma. Science 240:1772–4.
Cunningham, LL, Brandon, CS (2006) Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death. J Assoc Res Otolaryngol 7:299–307.
Cunningham, LL, Cheng, AG, Rubel, EW (2002) Caspase activation in hair cells of the mouse utricle exposed to neomycin. J Neurosci 22:8532–40.
Cunningham, LL, Matsui, JI, Warchol, ME, Rubel, EW (2004) Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro. J Neurobiol 60:89–100.
Dechant, G, Barde, YA (2002) The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci 5:1131–1136.
Dehne, N, Lautermann, J, Petrat, F, Rauen, U, de Groot, H (2001) Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals. Toxicol Appl Pharmacol 174:27–34.
Desai, SS, Zeh, C, Lysakowski, A (2005) Comparative morphology of rodent vestibular periphery. I. Saccular and utricular maculae. J Neurophysiol 93:251–66.
Duan, M, Agerman, K, Ernfors, P, Canlon, B (2000) Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity. Proc Natl Acad Sci U S A 97:7597–602.
Fahnestock, M, Michalski, B, Xu, B, Coughlin, MD (2001) The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci 18:210–20.
Fausti, SA, Larson, VD, Noffsinger, D, Wilson, RH, Phillips, DS, Fowler, CG (1994) High-frequency audiometric monitoring strategies for early detection of ototoxicity. Ear Hear 15:232–9.
Fermin, CD, Igarashi, M (1983) Aminoglycoside ototoxicity in the chick (Gallus domesticus) inner ear: I. The effects of kanamycin and netilmicin on the basilar papilla. Am J Otolaryngol 4:174–83.
Forge, A, Li, L (2000) Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 139:97–115.
Forge, A, Schacht, J (2000) Aminoglycoside antibiotics. Audiol Neurootol 5:3–22.
Gale, JE, Marcotti, W, Kennedy, HJ, Kros, CJ, Richardson, GP (2001) FM1–43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J Neurosci 21:7013–25.
Garetz, SL, Altschuler, RA, Schacht, J (1994) Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear Res 77:81–7.
Gestwa, G, Wiechers, B, Zimmermann, U, Praetorius, M, Rohbock, K, Kopschall, I, Zenner, HP, Knipper, M (1999) Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function. J Comp Neurol 414:33–49.
Gillespie, LN, Clark, GM, Bartlett, PF, Marzella, PL (2003) BDNF-induced survival of auditory neurons in vivo: Cessation of treatment leads to accelerated loss of survival effects. J Neurosci Res 71:785–90.
Gonzalez, GA, Montminy, MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675–80.
Gross, A, McDonnell, JM, Korsmeyer, SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899–911.
Hahn, H, Müller, M, Löwenheim, H (2008) Whole organ culture of the postnatal sensory inner ear in simulated microgravity. J Neurosci Methods 171:60–71.
Hansen, MR, Zha, XM, Bok, J, Green, SH (2001) Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro. J Neurosci 21:2256–67.
Hansen, MR, Roehm, PC, Xu, N, Green, SH (2007) Overexpression of Bcl-2 or Bcl-xL prevents spiral ganglion neuron death and inhibits neurite growth. Dev Neurobiol 67:316–25.
Hashino, E, Shero, M, Salvi, RJ (1997) Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells. Brain Res 777:75–85.
Hausheer, FH, Kanter, P, Cao, S, Haridas, K, Seetharamulu, P, Reddy, D, Petluru, P, Zhao, M, Murali, D, Saxe, JD, Yao, S, Martinez, N, Zukowski, A, Rustum, YM (1998) Modulation of platinum-induced toxicities and therapeutic index: mechanistic insights and first- and second-generation protecting agents. Semin Oncol 25:584–99.
HawkinsJE, Jr JE, Jr., Lurie, MH (1952) The ototoxicity of streptomycin. Ann Otol Rhinol Laryngol 61:789–809.
Hegarty, JL, Kay, AR, Green, SH (1997) Trophic support of cultured spiral ganglion neurons by depolarization exceeds and is additive with that by neurotrophins or cAMP and requires elevation of [Ca2+]i within a set range. J Neurosci 17:1959–70.
Hille, B (2001) Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer Associates.
Hinshaw, H, Feldman, W (1945) Streptomycin in treatment of clinical tuberculosis: A preliminary report. Proc Mayo Clin 20:313–18.
Holley, MC (2005) Keynote review: The auditory system, hearing loss and potential targets for drug development. Drug Discov Today 10:1269–82.
Huang, EJ, Reichardt, LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677–736.
Huang, EJ, Reichardt, LF (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72:609–42.
Hurley, PA, Crook, JM, Shepherd, RK (2007) Schwann cells revert to non-myelinating phenotypes in the deafened rat cochlea. Eur J Neurosci 26:1813–21.
Ip, YT, Davis, RJ (1998) Signal transduction by the c-Jun N-terminal kinase (JNK)–from inflammation to development. Curr Opin Cell Biol 10:205–19.
Jaattela, M, Wissing, D, Kokholm, K, Kallunki, T, Egeblad, M (1998) Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 17:6124–34.
Jiang, H, Talaska, AE, Schacht, J, Sha, SH (2007) Oxidative imbalance in the aging inner ear. Neurobiol Aging 28:1605–12.
Kanzaki, S, Stover, T, Kawamoto, K, Prieskorn, DM, Altschuler, RA, Miller, JM, Raphael, Y (2002) Glial cell line-derived neurotrophic factor and chronic electrical stimulation prevent VIII cranial nerve degeneration following denervation. J Comp Neurol 454:350–60.
Knight, KR, Kraemer, DF, Neuwelt, EA (2005) Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development. J Clin Oncol 23:8588–96.
Knipper, M, Kopschall, I, Rohbock, K, Kopke, AK, Bonk, I, Zimmermann, U, Zenner, H (1997) Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear. Cell Tissue Res 287:23–41.
Lang, H, Liu, C (1997) Apoptosis and hair cell degeneration in the vestibular sensory epithelia of the guinea pig following a gentamicin insult. Hear Res 111:177–84.
Lang, H, Schulte, BA, Schmiedt, RA (2005) Ouabain induces apoptotic cell death in type I spiral ganglion neurons, but not type II neurons. J Assoc Res Otolaryngol 6:63–74.
Layton, MG, Robertson, D, Everett, AW, Mulders, WH, Yates, GK (2005) Cellular localization of voltage-gated calcium channels and synaptic vesicle-associated proteins in the guinea pig cochlea. J Mol Neurosci 27:225–44.
Lee, JE, Nakagawa, T, Kim, TS, Iguchi, F, Endo, T, Dong, Y, Yuki, K, Naito, Y, Lee, SH, Ito, J (2003) A novel model for rapid induction of apoptosis in spiral ganglions of mice. Laryngoscope 113:994–9.
Lenoir, M, Puel, JL (1987) Dose-dependent changes in the rat cochlea following aminoglycoside intoxication. II. Histological study. Hear Res 26:199–209.
Lessmann, V, Gottmann, K, Malcangio, M (2003) Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 69:341–74.
Li, CY, Lee, JS, Ko, YG, Kim, JI, Seo, JS (2000) Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 275:25665–71.
Li, L, Nevill, G, Forge, A (1995) Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear. J Comp Neurol 355:405–17.
Liu, W, Staecker, H, Stupak, H, Malgrange, B, Lefebvre, P, Van De Water, TR (1998) Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 9:2609–14.
Lonze, BE, Ginty, DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605–23.
Marber, MS, Mestril, R, Chi, SH, Sayen, MR, Yellon, DM, Dillmann, WH (1995) Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 95:1446–56.
Marchenko, ND, Zaika, A, Moll, UM (2000) Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 275:16202–12.
Marcotti, W, van Netten, SM, Kros, CJ (2005) The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol 567:505–21.
Martindale, JL, Holbrook, NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1–15.
Matsui, JI, Ogilvie, JM, Warchol, ME (2002) Inhibition of caspases prevents ototoxic and ongoing hair cell death. J Neurosci 22:1218–27.
Matsui, JI, Haque, A, Huss, D, Messana, EP, Alosi, JA, Roberson, DW, Cotanche, DA, Dickman, JD, Warchol, ME (2003) Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci 23:6111–22.
Minichiello, L, Piehl, F, Vazquez, E, Schimmang, T, Hokfelt, T, Represa, J, Klein, R (1995) Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development 121:4067–75.
Mosser, DD, Caron, AW, Bourget, L, Denis-Larose, C, Massie, B (1997) Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17:5317–27.
Niedzielski, AS, Wenthold, RJ (1995) Expression of AMPA, kainate, and NMDA receptor subunits in cochlear and vestibular ganglia. J Neurosci 15:2338–53.
Nykjaer, A, Willnow, TE, Petersen, CM (2005) p75NTR–live or let die. Curr Opin Neurobiol 15:49–57.
Oestreicher, E, Knipper, M, Arnold, A, Zenner, HP, Felix, D (2000) Neurotrophin 3 potentiates glutamatergic responses of IHC afferents in the cochlea in vivo. Eur J Neurosci 12:1584–90.
Ohlemiller, KK, McFadden, SL, Ding, DL, Flood, DG, Reaume, AG, Hoffman, EK, Scott, RW, Wright, JS, Putcha, GV, Salvi, RJ (1999) Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol 4:237–46.
Oren, M (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10:431–42.
Owens, KN, Cunningham, DE, MacDonald, G, Rubel, EW, Raible, DW, Pujol, R (2007) Ultrastructural analysis of aminogly-coside-induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response. J Comp Neurol 502:522–43.
Pandey, P, Saleh, A, Nakazawa, A, Kumar, S, Srinivasula, SM, Kumar, V, Weichselbaum, R, Nalin, C, Alnemri, ES, Kufe, D, Kharbanda, S (2000) Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J 19:4310–22.
Pedraza, CE, Podlesniy, P, Vidal, N, Arevalo, JC, Lee, R, Hempstead, B, Ferrer, I, Iglesias, M, Espinet, C (2005) Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. Am J Pathol 166:533–43.
Pirvola, U, Xing-Qun, L, Virkkala, J, Saarma, M, Murakata, C, Camoratto, AM, Walton, KM, Ylikoski, J (2000) Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 20:43–50.
Plumier, JC, Krueger, AM, Currie, RW, Kontoyiannis, D, Kollias, G, Pagoulatos, GN (1997) Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury. Cell Stress Chaperones 2:162–7.
Priuska, EM, Schacht, J (1995) Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 50:1749–52.
Puel, JL (1995) Chemical synaptic transmission in the cochlea. Prog Neurobiol 47:449–76.
Qun, LX, Pirvola, U, Saarma, M, Ylikoski, J (1999) Neurotrophic factors in the auditory periphery. Ann N Y Acad Sci 884:292–304.
Radford, NB, Fina, M, Benjamin, IJ, Moreadith, RW, Graves, KH, Zhao, P, Gavva, S, Wiethoff, A, Sherry, AD, Malloy, CR, Williams, RS (1996) Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A 93:2339–42.
Raphael, Y, Altschuler, RA (2003) Structure and innervation of the cochlea. Brain Res Bull 60:397–22.
Ringstedt, T, Ibanez, CF, Nosrat, CA (1999) Role of brain-derived neurotrophic factor in target invasion in the gustatory system. J Neurosci 19:3507–18.
Robles, L, Ruggero, MA (2001) Mechanics of the mammalian cochlea. Physiol Rev 81:1305–52.
Rybak, LP, Ramkumar, V (2007) Ototoxicity. Kidney Int 72:931–5.
Rybak, LP, Whitworth, C, Somani, S (1999a) Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope 109:1740–4.
Rybak, LP, Husain, K, Whitworth, C, Somani, SM (1999b) Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. Toxicol Sci 47:195–202.
Salvesen, GS, Riedl, SJ (2008) Caspase mechanisms. Adv Exp Med Biol 615:13–23.
Sano, H, Yoneda, S, Iwase, H, Itoh, A, Hashimoto, D, Okamoto, M (2007) Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture. Auris Nasus Larynx 34:1–4.
Santi, PA, Blair, A, Bohne, BA, Lukkes, J, Nietfeld, J (2004) The digital cytocochleogram. Hear Res 192:75–82.
Schimmang, T, Minichiello, L, Vazquez, E, San Jose, I, Giraldez, F, Klein, R, Represa, J (1995) Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets. Development 121:3381–91.
Schimmang, T, Tan, J, Muller, M, Zimmermann, U, Rohbock, K, Kopschall, I, Limberger, A, Minichiello, L, Knipper, M (2003) Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss. Development 130:4741–50.
Schuler, M, Bossy-Wetzel, E, Goldstein, JC, Fitzgerald, P, Green, DR (2000) p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem 275:7337–42.
Sedletska, Y, Giraud-Panis, MJ, Malinge, JM (2005) Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways. Curr Med Chem Anticancer Agents 5:251–65.
Sha, SH, Schacht, J (2000) Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hear Res 142:34–40.
Shepherd, RK, Coco, A, Epp, SB, Crook, JM (2005) Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss. J Comp Neurol 486:145–58.
Shimizu, A, Takumida, M, Anniko, M, Suzuki, M (2003) Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity. Acta Otolaryngol 123:459–65.
Shimizu, S, Konishi, A, Kodama, T, Tsujimoto, Y (2000) BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A 97:3100–5.
Simon, T, Hero, B, Dupuis, W, Selle, B, Berthold, F (2002) The incidence of hearing impairment after successful treatment of neuroblastoma. Klin Padiatr 214:149–52.
Staecker, H, Liu, W, Malgrange, B, Lefebvre, PP, Van De Water, TR (2007) Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury. ORL J Otorhinolaryngol Relat Spec 69:43–50.
Stankovic, K, Rio, C, Xia, A, Sugawara, M, Adams, JC, Liberman, MC, Corfas, G (2004) Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci 24:8651–61.
Sugahara, K, Rubel, EW, Cunningham, LL (2006) JNK signaling in neomycin-induced vestibular hair cell death. Hear Res 221:128–35.
Sugahara, K, Inouye, S, Izu, H, Katoh, Y, Katsuki, K, Takemoto, T, Shimogori, H, Yamashita, H, Nakai, A (2003) Heat shock transcription factor HSF1 is required for survival of sensory hair cells against acoustic overexposure. Hear Res 182:88–96.
Tabuchi, K, Pak, K, Chavez, E, Ryan, AF (2007) Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage. Neuroscience 149:213–22.
Takumida, M, Anniko, M, Shimizu, A, Watanabe, H (2003) Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors. Acta Otolaryngol 123:8–13.
Taleb, M, Brandon, CS, Lee, FS, Lomax, MI, Dillmann, WH, Cunningham, LL (2008) Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol 9:277–89.
Tan, J, Shepherd, RK (2006) Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling. Am J Pathol 169:528–43.
Tan, J, Ruttiger, L, Panford-Walsh, R, Singer, W, Schulze, H, Kilian, SB, Hadjab, S, Zimmermann, U, Kopschall, I, Rohbock, K, Knipper, M (2007) Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma. Neuroscience 145:715–26.
Tao, X, Finkbeiner, S, Arnold, DB, Shaywitz, AJ, Greenberg, ME (1998) Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20:709–26.
Teng, HK, Teng, KK, Lee, R, Wright, S, Tevar, S, Almeida, RD, Kermani, P, Torkin, R, Chen, ZY, Lee, FS, Kraemer, RT, Nykjaer, A, Hempstead, BL (2005) ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455–63.
Tran, Ba Huy P, Bernard, P, Schacht, J (1986) Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. J Clin Invest 77:1492–500.
Trimmer, EE, Essigmann, JM (1999) Cisplatin. Essays Biochem 34:191–211.
Tsuchiya, D, Hong, S, Matsumori, Y, Shiina, H, Kayama, T, Swanson, RA, Dillman, WH, Liu, J, Panter, SS, Weinstein, PR (2003) Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia. J Cereb Blood Flow Metab 23:718–27.
Vago, P, Humbert, G, Lenoir, M (1998) Amikacin intoxication induces apoptosis and cell proliferation in rat organ of Corti. Neuroreport 9:431–6.
van Ruijven, MW, de Groot, JC, Hendriksen, F, Smoorenburg, GF (2005a) Immunohistochemical detection of platinated DNA in the cochlea of cisplatin-treated guinea pigs. Hear Res 203:112–21.
van Ruijven, MW, de Groot, JC, Klis, SF, Smoorenburg, GF (2005b) The cochlear targets of cisplatin: an electrophysiological and morphological time-sequence study. Hear Res 205:241–8.
Vollrath, MA, Kwan, KY, Corey, DP (2007) The micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci 30:339–65.
Wang, J, Lloyd Faulconbridge, RV, Fetoni, A, Guitton, MJ, Pujol, R, Puel, JL (2003a) Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig. Neuropharmacology 45:380–93.
Wang, J, Van De Water, TR, Bonny, C, de Ribaupierre, F, Puel, JL, Zine, A (2003b) A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 23:8596–607.
Wang, J, Ladrech, S, Pujol, R, Brabet, P, Van De Water, TR, Puel, JL (2004) Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. Cancer Res 64:9217–24.
West, AE, Griffith, EC, Greenberg, ME (2002) Regulation of transcription factors by neuronal activity. Nat Rev Neurosci 3:921–31.
Wiechers, B, Gestwa, G, Mack, A, Carroll, P, Zenner, HP, Knipper, M (1999) A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and mice. J Neurosci 19:3033–42.
Williams, JA, Holder, N (2000) Cell turnover in neuromasts of zebrafish larvae. Hear Res 143:171–81.
Wise, AK, Richardson, R, Hardman, J, Clark, G, O’Leary, S (2005) Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3. J Comp Neurol 487:147–65.
Yamashita, D, Minami, SB, Kanzaki, S, Ogawa, K, Miller, JM (2008) Bcl-2 genes regulate noise-induced hearing loss. J Neurosci Res 86:920–8.
Yenari, MA, Fink, SL, Sun, GH, Chang, LK, Patel, MK, Kunis, DM, Onley, D, Ho, DY, Sapolsky, RM, Steinberg, GK (1998) Gene therapy with Hsp72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol 44:584–91.
Ylikoski, J, Xing-Qun, L, Virkkala, J, Pirvola, U (2002) Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 163:71–81.
Ylikoski, J, Pirvola, U, Moshnyakov, M, Palgi, J, Arumae, U, Saarma, M (1993) Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear. Hear Res 65:69–78.
Yoshida, N, Kristiansen, A, Liberman, MC (1999) Heat stress and protection from permanent acoustic injury in mice. J Neurosci 19:10116–24.
Zhang, M, Liu, W, Ding, D, Salvi, R (2003) Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Neuroscience 120:191–205.
Zou, H, Li, Y, Liu, X, Wang, X (1999) An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274:11549–56.

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