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Distribution of human chromosomes on the metaphase plate. Symmetrical arrangement in human male cells

Published online by Cambridge University Press:  14 April 2009

M. Dolores Coll ,
Carlos M. Cuadras  and
Jose Egozcue
M. Dolores Coll
Affiliation:
Department of Cell Biology, Faculty of Science, and Instituto de Biología Fundamental, Universidad Autónoma de Barcelona, Barcelona, Spain
Carlos M. Cuadras
Affiliation:
Department of Genetics (Biostatistics), Faculty of Biology, University of Barcelona, Barcelona, Spain
Jose Egozcue
Affiliation:
Department of Cell Biology, Faculty of Science, and Instituto de Biología Fundamental, Universidad Autónoma de Barcelona, Barcelona, Spain
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Two linear models have been devised and applied to the study of the distribution of human male chromosomes on the metaphase plate in preparations from lymphocyte cultures not treated with spindle poisons. Using these it has been found that the chromosomes are approximately distributed around a centre of symmetry and that the lines joining the centromeres of homologous chromosomes (i.e. segments) have the centre of symmetry approximately at their mid-point. Thus each chromosome mirrors the position of its homologue relative to the centre of symmetry. The position of each chromosome in the metaphase plate was found to be approximately constant relative to the centre of symmetry and the other chromosomes. The significance of these findings is discussed in relation to the hypothesis on the distribution of the chromosomes in interphase nuclei and to data on acrocentric associations, acrocentric-non-acrocentric associations and the frequency of the most common translocations.

Type
Research Article
Information
Genetics Research , Volume 36 , Issue 3 , December 1980 , pp. 219 - 234
Copyright
Copyright © Cambridge University Press 1980

References

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