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The Protective effect of irradiated metacercariae of Fasciola gigantica against homologous challenge in sheep

Published online by Cambridge University Press:  05 June 2009

Haga A/gadir ,
E. M. Haroun  and
A. A. Gameel
Haga A/gadir
Affiliation:
Faculty of Veterinary Science, University of Khartoum, Khartoum North, P.O. Box 32, Sudan.
E. M. Haroun*
Affiliation:
Faculty of Veterinary Science, University of Khartoum, Khartoum North, P.O. Box 32, Sudan.
A. A. Gameel
Affiliation:
Faculty of Veterinary Science, University of Khartoum, Khartoum North, P.O. Box 32, Sudan.
*
*College of Agriculture and Veterinary Medicine, Gasseem, Buraydah, P.O. Box 1482, Saudi Arabia
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Abstract

Five lambs were each sensitized with 400 metacercariae of Fasciola gigantica irradiated at 3 kr gammarays. Eight weeks later, they were each challenged together with 5 controls with 500 non-irradiated metacercariae. Eight weeks later, all of the animals were necropsied and the worm burdens determined. The lambs which received the sensitizing infections had 80% less worms than the controls. The sensitized lambs also showed less hepatic damage compared with the controls as indicated by lower levels of the serum enzyme glutamate dehydrogenase. The blood indices showed insigicant reductions in the sensitized lambs whereas marked reductions were found in the erythrocytes, packed cell volume and haemoglobin values of the challenge controls. Bilirubinaemia was also evident in this latter group.

Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 137 - 142
Copyright
Copyright © Cambridge University Press 1987

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References

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