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An experimental study on cellular immunity in Pasteurella pestis infection

Published online by Cambridge University Press:  15 May 2009

S. S. Bhatnagar  and
D. L. Shrivastava
S. S. Bhatnagar
Affiliation:
From the Haffkine Institute, Bombay
D. L. Shrivastava
Affiliation:
From the Haffkine Institute, Bombay
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1. Animals susceptible and naturally immune to plague—Bombay rats and white mice—were infected with Past, pestis and supravital study of white blood cells from the peripheral blood stream carried out. Similar studies were made on white mice injected with (a) pure envelope serum, (b) pure somatic serum, and (c) whole antiplague serum.

2. Different experimental conditions produced different cell pictures with different behaviours of individual cell types, especially the polymorpho-nuclears, the monocytes and the clasmatocytes. These abnormalities were found to bear distinctive relationship to (a) active immunity, (b) passive immunity, and (c) susceptibility on the part of the experimental animal.

3. The value of immunological inferences from this study in relation to plague-serum therapy and plague prophylaxis has been emphasized.

4. The possibility of a better understanding of host-parasite relationships from similar studies in other bacterial infections has been pointed out.

Our thanks are due to Lt.-Col. S. S. Sokhey, I.M.S., Director Haffkine Institute, for his interest in this investigation.

Type
Research Article
Information
Journal of Hygiene , Volume 44 , Issue 5 , May 1946 , pp. 307 - 313
Copyright
Copyright © Cambridge University Press 1946

References

REFERENCES

Aschoff, L. & Kiyono, K. (1913). Folia haemat., Lpz., 15, 383.Google Scholar
Bhatnagar, S. S. (1940 a). Indian J. Med. Res. 28, 1.Google Scholar
Bhatnagar, S. S. (1940 b). Indian J. Med. Res. 28, 16.Google Scholar
Bhatnagar, S. S. & Kamat, G. K. (1946). Indian J. Med. Res. (in the Press).Google Scholar
Carrel, A. & Ebeling, A. H. (1926). J. Exp. Med. 43, 461.CrossRefGoogle Scholar
Cunningham, B. S., Sabin, F. R. & Doan, C. A. (1925). Contr. Embryol. Carneg. Instn, 16, 227.Google Scholar
Gay, F. P. (1935). Agents of Disease and Host Resistance, p. 296.Google Scholar
Gay, F. P. & Morrison, L. F. (1923). J. Inject. Dis. 33, 338.CrossRefGoogle Scholar
Heidelberger, M. & Kendall, F. P. (1933). J. Infect. Dis. 58, 137Google Scholar
Heidelberger, M. & Kendall, F. P. (1934). J. Infect. Dis. 59, 519.Google Scholar
Heidelberger, M. & Kendall, F. P. (1935). J. Infect. Dis. 62, 467.Google Scholar
Ranvier, L. (1890). C.R. Acad. Sci., Paris, 110, 165.Google Scholar
Sabin, F. R. (1923). Johns Hopk. Hosp. Bull. 34, 27.Google Scholar
Sabin, F. R. (1939). J. Exp. Med. 70, 67.CrossRefGoogle Scholar
Sabin, F. R., Cunningham, R. S., Doan, C. A. & Kindwall, J. A. (1925 a). Johns Hopk. Hosp. Bull. 37, 14.Google Scholar
Sabin, F. R., Doan, C. A. & Conningham, R. S. (1925 b). Contr. Embryol. Carneg. Instn, 16, 125.Google Scholar
Schütze, H. (1932). Brit. J. Exp. Path. 13, 284.Google Scholar
Schütze, H. (1934). Brit. J.Exp. Path. 15, 200.Google Scholar
Shaw, A. F. B. (1927). J. Path. Bact. 30, 1.CrossRefGoogle Scholar
Sokhey, S. S. (1939). Indian J. Med. Res. 27, 341.Google Scholar