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Quantitative study of the sterilization of bacteria by mercuric compounds

Published online by Cambridge University Press:  15 May 2009

J. A. de Loureiro  and
Eugenio Lito
J. A. de Loureiro
Affiliation:
Faculty of Medicine, Lisbon.
Eugenio Lito
Affiliation:
Faculty of Medicine, Lisbon.
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In the present work it is suggested that the sterilization of bacterial suspensions by mercurial antiseptics is a reflexion of a possible stoichiometrical relation between the mercuric compound and the thiol receptors in the bacterial cells.

This has been verified experimentally by studying the times of survival of suspensions of B. typhosum mixed with multiples and submultiples of the quantity of antiseptic theoretically equivalent to the thiol content of the suspension, as estimated by iodometric titration.

The considerable differences observed in the time of survival of suspensions mixed respectively with more and with less than the thiol equivalent of antiseptic, and the absence of any marked effect of dilution of the mixture, show that there is a quantitative relationship between the amounts of substrate and the quantity of antiseptic capable of sterilizing it.

Type
Research Article
Information
Journal of Hygiene , Volume 44 , Issue 6 , September 1946 , pp. 463 - 470
Copyright
Copyright © Cambridge University Press 1946

References

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