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Protection of mice against Babesia spp. and plasmodium spp. with killed Corynebacterium parvum

Published online by Cambridge University Press:  06 April 2009

I. A. Cleark ,
F. E. G Cox  and
A. C. Allison
I. A. Cleark
Affiliation:
Division of Cell Pathology, Clinical Research Center, Watford Road, Harrow, Middlesex HA1 3UJ and Department of Zoology, University of London, The Strand, London WC2
F. E. G Cox
Affiliation:
Division of Cell Pathology, Clinical Research Center, Watford Road, Harrow, Middlesex HA1 3UJ and Department of Zoology, University of London, The Strand, London WC2
A. C. Allison
Affiliation:
Division of Cell Pathology, Clinical Research Center, Watford Road, Harrow, Middlesex HA1 3UJ and Department of Zoology, University of London, The Strand, London WC2
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Extract

Mice which had been pre-treated with killed Corynebacterium parvum given intravenously or intraperitoneally, but not subcutaneously, were completely resistant ot infection withBabesia microti or B. rodhaini, and protected from death caused by Plasmodium vinckeior P. chabaudiinfection. There is evidence that the parasites died within circulating erythrocytes. This occurred much too soon for a specific antibody response to be evoked, and no antibody could be detected by the indirect fluorescent-anitbody technique. Thus it is suggested that a non-secific soluble mediator may play an important role in the protection observed.

Type
Research Article
Information
Parasitology , Volume 74 , Issue 1 , February 1977 , pp. 9 - 18
Copyright
Copyright © Cambridge University Press 1977

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References

Adlam, C., Broughton, E. S. & Scott, M. T. (1972). Enhanced resistance of mice to infection with bacteria following treatment with Corynebacterium parvum. Nature, New Biology 235, 219–20.Google Scholar
Cerutti, I. (1974). Propiétés antivirales du C. parvum. Compte rendu hebdomadaire des séances de ľ Académie des sciences 279, 963–6.Google Scholar
Clark, I. A., Allison, A. C. & Cox, F. E. G. (1976). Protection of mice against Babesia and Plasmodium with BCG. Nature, London 259, 309–11.CrossRefGoogle ScholarPubMed
Clark, I. A., Richmond, J. E., Wills, E. J. & Allison, A. C. (1975). Immunity to intraerythrocytic protozoa. Lancet 2, 1128–9.CrossRefGoogle Scholar
Collins, F. M. & Scott, M. T. (1974). Effect of Corynebacterium parvum of the growth of Salmonella entreitidis in mice. Infection and Immunity 9, 863–9.CrossRefGoogle Scholar
Halpern, B. N., Prevot, A. R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J. C., Bouthillier, Y. & Decruesefond, C. (1964). Stimulation de ľ activité phagocytaire du systeme rĺticulo-endothelial provoquĺe par Corynebacterium parvum. Jounral of the Reticuloendothelial Society 1, 77–96.Google Scholar
Howard, J. G., Scott, M. T. & Christle, G. H. (1973). Cellular mechanisms underlying the adjuvant activity of Corynebacterium parvum: interaction of activated macrophages with T and B lymphocytes. In Immunopotentiation: Ciba Foundation Symposium 18 (ed. Knight, J. and Wolstenholme, G. E. H.), pp. 101–14. Amsterdam: Elsevier.Google Scholar
Kierszenbaum, F. (1975). Enhancement of resistance and suppression of immunization against experimental Trypansosoma cruzi infection by Corynebacterium parvum. Infection and Immunity 12, 1227–9.CrossRefGoogle Scholar
Neveu, T., Bronellec, A. & Biozzi, G. (1964). Propiétés adjuvantes du Corynebacterium parvum sur la production ď anticorps et sur ĺ induction de ĺ hypersensibilité retardée envers les protéines conjuguées. Annals Institute Pasteur 106, 771–7.Google Scholar
Nussenzweig, R. S. (1967). Increased nonspecific resistance to malaria produced by administration of killed Corynebacterium parvum. Experimental Parasitology 21, 224–31.CrossRefGoogle Scholar
Scott, M. T. (1974). Corynebacterium parvum asan immunotherapeutic cancer agent. Seminars in Oncology 1, 367–78.Google Scholar
Senterfitt, V.C. & Shands, J. W. (1970). Salmonellosis in mice infected with Mycobacterium bovis BCG. II. Resistance to infection. Infection and Immunity 1, 583–6.Google Scholar
Sher, N. A., Chaparas, S. D., Greenberg, L. E. & Bernard, S. (1975). Effects of BCG, Corynebacterium parvum and methanol extract residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice. Infection and Immunity 12, 1325–30.Google Scholar
Stuart, A. E., Habeshaw, J. A. & Davidsion, A. E. (1973). Phagocytes in vitro. In Handbook of Experimental Immunology, 2nd ed. (ed. Weir, D. M.), pp. 24.1–24.26. Oxford: Blackwell.Google Scholar
Swartzberg, J. E., Krahenbuhl, J. L. & Remington., J. S. (1975). Dihotomy between macrophage activation and degree of protection against Listeria monocytogenes and Toxoplasma gondii in mice stimulated with Corynebacterium parvum. Infection and Immunity 12, 1037–43.CrossRefGoogle ScholarPubMed
Voller, A. & ÓNeill, P. (1971). Immunofluorescence method suitable fro large-scale application to malaria. Bulletion of the World Health Organization 45, 524–9.Google Scholar