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Evidence for the involvement of a bone marrow-derived cell population in the immune expulsion of Trichinella spiralis

Published online by Cambridge University Press:  06 April 2009

D. Wakelin  and
Margaret M. Wilson
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Paraistology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
Margaret M. Wilson
Affiliation:
Wellcome Laboratories for Experimental Paraistology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
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Extract

When mice were irradiated immediately before infection with Trichinella spiralis there was a profound and long-lasting interference with their ability to expel adult worms from the intestine. Irradiation given after the fifth day of infection was progressively less effective in this respect. The ability to expel worms was not restored when mesenteric lymph node cells (MLNC) were transferred (a) on the day of infection in mice irradiated one day previously, or (b) on day 7 of an infection in mice irradiated on day 6, even though the MLNC transferred immunity to intact recipients. Transfer of bone marrow (BM) alone was also without effect. However, worm explusion was restored if, following irradiation and injection of BM, 10 days were allowed for BM differentiation before transfer of MLNC. This restoration was effective even after lethal levels of irradiation and was clearly dependent upon a donor-derived BM component cooperating with, or responding to, the activity of the transferred MLNC. The possibility that the BM component is non-lymphoid in nature is discussed.

Type
Research Article
Information
Parasitology , Volume 74 , Issue 3 , June 1977 , pp. 225 - 234
Copyright
Copyright © Cambridge University Press 1977

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