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The biology of Plasmodium falciparum transmission stages

Published online by Cambridge University Press:  16 March 2011

K. P. Day ,
R. E. Hayward  and
M. Dyer
K. P. Day*
Affiliation:
The Wellcome Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK
R. E. Hayward
Affiliation:
The Wellcome Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK
M. Dyer
Affiliation:
The Wellcome Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK
*
*Corresponding author
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Summary

The most important function of any parasite is to secure transmission to new hosts. The gametocyte, the stage which has become developmentally committed to the sexual cycle, provides a critical link in the transmission of Plasmodium falciparum from the human host to the anopheline mosquito vector. It is therefore imperative that our determination to understand the biology of the gametocyte is greater than the technical obstacles which have resulted in the gametocyte being left very much out of the limelight by the intensive investigation of the asexual bloodstream parasite. Here we explore the areas of gametocyte biology which by nature of their relevance to control and pathology as well as basic biology, are the subjects of investigation in our laboratory. We also point out areas in need of particular attention.

Keywords

malariatransmissiongametocytesadhesiondiversity
Type
Research Article
Information
Parasitology , Volume 116 , supplement S1: Symposia of the British Society for Parasitology Volume 35: Parasite-insect interactions: reciprocal manipulation , 1998 , pp. S95 - S109
Copyright
Copyright © Cambridge University Press 1998

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