Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-24T07:51:48.247Z Has data issue: false hasContentIssue false
  • English
  • Français

Anamnestic responses in pigs to the Taenia solium TSOL18 vaccine and implications for control strategies

Published online by Cambridge University Press:  19 February 2016

MARSHALL W. LIGHTOWLERS ,
MERITXELL DONADEU ,
M. ELAIYARAJA ,
KAPIL MAITHAL ,
K. ANAND KUMAR ,
CHARLES G. GAUCI ,
SIMON M. FIRESTONE ,
PATXI SARASOLA  and
TIM G. ROWAN
MARSHALL W. LIGHTOWLERS*
Affiliation:
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
MERITXELL DONADEU
Affiliation:
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
M. ELAIYARAJA
Affiliation:
Indian Immunologicals Limited, ‘Rakshapuram’, Gachibowli Post, Hyderabad - 500 032, Telangana, India
KAPIL MAITHAL
Affiliation:
Indian Immunologicals Limited, ‘Rakshapuram’, Gachibowli Post, Hyderabad - 500 032, Telangana, India
K. ANAND KUMAR
Affiliation:
Indian Immunologicals Limited, ‘Rakshapuram’, Gachibowli Post, Hyderabad - 500 032, Telangana, India
CHARLES G. GAUCI
Affiliation:
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
SIMON M. FIRESTONE
Affiliation:
Faculty of Veterinary and Agricultural Sciences, Asia-Pacific Centre for Animal Health, The University of Melbourne, Parkville, Victoria 3010, Australia
PATXI SARASOLA
Affiliation:
Ondax Scientific SL, Aptdo. 336, 20280 Hondarribia, Spain
TIM G. ROWAN
Affiliation:
GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, Scotland, UK
*
*Corresponding author. Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia. E-mail: marshall@unimelb.edu.au
Get access Rights & Permissions [Opens in a new window]

Summary

Specific antibody responses were assessed in pigs immunized with the Taenia solium vaccine TSOL18. Anti-TSOL18 responses were compared 2 weeks after secondary immunization, where the interval between primary and secondary immunization was 4, 8, 12, 16 or 20 weeks. All animals responded to the vaccine and there was no diminution in antibody responses in animals receiving their second injection after an interval up to 20 weeks. Pigs receiving vaccinations at an interval of 12 weeks developed significantly increased antibody responses compared with animals receiving immunizations 4 weeks apart (P = 0·046). The ability to deliver TSOL18 vaccination effectively where the revaccination schedule can be delayed for up to 12–16 weeks in pigs increases the options available for designing T. solium control interventions that incorporate TSOL18 vaccination.

Keywords

Taenia soliumpigvaccineTSOL18anamnestic response
Type
Research Article
Information
Parasitology , Volume 143 , Issue 4 , April 2016 , pp. 416 - 420
Check for updates
Copyright
Copyright © Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anonymous (1992). Update: international task force for disease eradication, 1992. Morbidity and Mortality Weekly Report 41, 691, 697–691.Google Scholar
Assana, E., Kyngdon, C. T., Gauci, C. G., Geerts, S., Dorny, P., De Deken, R., Anderson, G. A., Zoli, A. P. and Lightowlers, M. W. (2010). Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon. International Journal for Parasitology 40, 515–519.Google Scholar
Flisser, A., Gauci, C. G., Zoli, A., Martinez-Ocana, J., Garza-Rodriguez, A., Dominguez-Alpizar, J. L., Maravilla, P., Rodriguez-Canul, R., Avila, G., Aguilar-Vega, L., Kyngdon, C., Geerts, S. and Lightowlers, M. W. (2004). Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infection and Immunity 72, 5292–5297.CrossRefGoogle ScholarPubMed
Gonzales, A. E., Garcia, H. H., Gilman, R. H., Gavidia, C. M., Tsang, V. C., Bernal, T., Falcon, N., Romero, M. and Lopez-Urbina, M. T. (1996). Effective, single-dose treatment or porcine cysticercosis with oxfendazole. American Journal of Tropical Medicine and Hygiene 54, 391–394.CrossRefGoogle ScholarPubMed
Gonzalez, A. E., Falcon, N., Gavidia, C., Garcia, H. H., Tsang, V. C., Bernal, T., Romero, M. and Gilman, R. H. (1997). Treatment of porcine cysticercosis with oxfendazole: a dose-response trial. Veterinary Record 141, 420–422.CrossRefGoogle ScholarPubMed
Gonzalez, A. E., Gauci, C. G., Barber, D., Gilman, R. H., Tsang, V. C., Garcia, H. H., Verastegui, M. and Lightowlers, M. W. (2005). Vaccination of pigs to control human neurocysticercosis. American Journal of Tropical Medicine and Hygiene 72, 837–839.Google Scholar
Kyngdon, C. T. (2005). Studies on immune responses to taeniid cestode antigens . Ph.D. thesis. University of Melbourne, Australia.Google Scholar
Kyngdon, C. T., Gauci, C. G., Gonzalez, A. E., Flisser, A., Zoli, A., Read, A. J., Martinez-Ocana, J., Strugnell, R. A. and Lightowlers, M. W. (2006). Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A. Parasite Immunology 28, 191–199.Google Scholar
Lightowlers, M. W. (2006). Cestode vaccines: origins, current status and future prospects. Parasitology 133, S27–42.Google Scholar
Lightowlers, M. W. (2010). Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. International Journal for Parasitology 40, 1183–1192.Google Scholar
Lightowlers, M. W. (2013). Control of Taenia solium taeniasis/cysticercosis: past practices and new possibilities. Parasitology 140, 1566–1577.CrossRefGoogle ScholarPubMed
Ndimubanzi, P. C., Carabin, H., Budke, C. M., Nguyen, H., Qian, Y. J., Rainwater, E., Dickey, M., Reynolds, S. and Stoner, J. A. (2010). A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Neglected Tropical Diseases 4, e870.CrossRefGoogle ScholarPubMed
Schantz, P. M., Cruz, M., Sarti, E. and Pawlowski, Z. (1993). Potential eradicability of taeniasis and cysticercosis. Bulletin of the Pan American Health Organization 27, 397–403.Google Scholar
Sikasunge, C. S., Johansen, M. V., Willingham, A. L. III, Leifsson, P. S. and Phiri, I. K. (2008). Taenia solium porcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole. Veterinary Parasitology 158, 57–66.Google Scholar
Stratton, J., Chiruvolu, V. and Meagher, M. (1998). High cell-density fermentation. Methods in Molecular Biology 103, 107–120.CrossRefGoogle ScholarPubMed
World Health Organization (2015). Investing to overcome the global impact of Neglected Tropical Diseases. Third WHO Report on Neglected Tropical Diseases. WHO/HTM/NTD/2015.1, Geneva, Switzerland.Google Scholar