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A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11

Published online by Cambridge University Press:  09 July 2009

M. Gill ,
P. McGuffin ,
E. Parfitt ,
R. Mant ,
P. Asherson ,
D. Collier ,
H. Vallada ,
J. Powell ,
S. Shaikh  and
C. Taylor
...Show all authors
M. Gill*
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
P. McGuffin
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
E. Parfitt
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
R. Mant
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
P. Asherson
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
D. Collier
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
H. Vallada
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
J. Powell
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
S. Shaikh
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
C. Taylor
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
M. Sargeant
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
A. Clements
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
S. Nanko
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
N. Takazawa
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
D. Llewellyn
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
J. Williams
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
S. Whatley
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
R. Murray
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
M. Owen
Affiliation:
Genetics Section, Department of Psychiatry and Department of Neurosciences, Institute of Psychiatry, London; Department of Psychological Medicine, Department of Medical Genetics and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
*
1Address for correspondence: Dr M.Gill, Genetics Section, Department of Psychiatry, Institute of Psychiatry, De Crespigny Park. London SE5 8AF.
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Synopsis

We report the results of a collaborative linkage study using 12 polymorphic markers (9 loci) from the long arm of chromosome 11, and 24 families multiply affected with schizophrenia and other closely related disorders. This region is of interest because several families have been reported in which balanced translocations involving 11q apparently co-segregate with psychotic illness. In addition, the dopamine D2 receptor, porphobilinogen deaminase, and tyrosinase genes map within the region studied and may be aetiologically involved in schizophrenia. We have primarily analysed genotypic data by the LOD score method using a range of single gene models. In order to minimize error due to mis-specification of genetic parameters we have analysed data from markers at candidate gene loci by the non-parametric extended sib-pair method in addition to the LOD score method. Our results suggest that most of the region can be excluded from containing a gene of major effect in the aetiology of this disease.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 1 , February 1993 , pp. 27 - 44
Copyright
Copyright © Cambridge University Press 1993

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