Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-05-13T08:02:08.529Z Has data issue: false hasContentIssue false

Descriptive studies of H-reflex recovery curves in psychiatric patients

Published online by Cambridge University Press:  09 July 2009

John Metz*
Affiliation:
Department of Psychiatry, University of ChicagoPritzker School of Medicine, Chicago, Illinois, USA
David J. Goode
Affiliation:
Department of Psychiatry, University of ChicagoPritzker School of Medicine, Chicago, Illinois, USA
Herbert Y. Meltzer
Affiliation:
Department of Psychiatry, University of ChicagoPritzker School of Medicine, Chicago, Illinois, USA
*
1Address for correspondence: Dr John Metz, Illinois Mental Health Institutes, 1601 West Taylor Street, Chicago, Illinois 60612, USA.

Synopsis

The rate of recovery of the H-reflex, an electrical evoked monosynaptic spinal cord reflex, was abnormally high (fast) in over 20% of unmedicated psychotic patients of all major diagnostic classes. A few patients had significantly lower H-reflex recovery curves. Chronic neuroleptic treatment produced relatively lower recovery curves, whereas fluoxetine, a specific serotonin uptake blocker, produced relatively higher curves.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Braddom, R. L. & Johnson, E. W. (1974). H reflex: review and classification with suggested clinical uses. Archives of Physical Medicine and Rehabilitation 55, 412417.Google ScholarPubMed
Carlsson, A. & Lindqvist, M. (1962). In vivo decarboxylation of alpha-methyl-DOPA and alpha-methyl-metatyrosine. Acta physiologica scandinavica 54, 8794.CrossRefGoogle ScholarPubMed
Costall, B., Naylor, R. J., Marsden, C. D. & Pycock, C. J. (1976). Serotonergic modulation of the dopamine response from the nucleus accumbens. Journal of Pharmacy and Pharmacology 28, 523526.CrossRefGoogle Scholar
Crayton, J. W., Meltzer, H. Y. & Goode, D. J. (1977 a). Motoneuron excitability in psychiatric patients. Biological Psychiatry 12, 545561.Google ScholarPubMed
Crayton, J. W., Smith, R. C., Klass, D., Chang, S. & Erickson, S. (1977 b). Electrophysiological (H-reflex) studies of patients with tardive dyskinesia. American Journal of Psychiatry 134, 775781.Google ScholarPubMed
Dixon, W. J. & May, P. R. A. (1968). Methods of statistical analysis. In Treatment of Schizophrenia (ed. May, P. R. A.), pp. 106125. Science House: New York.Google Scholar
Dixon, W. J. & Tukey, J. W. (1968). Approximate behavior of the distribution of Winsorized t (Trimming/Winsorization 2). Technometrics 10, 8398.Google Scholar
Dray, A., Davies, J., Oakley, N. R., Tongroach, P. & Vellucci, S. (1978). The dorsal and medial raphe projections to the substantia nigra in the rat: electrophysiological, biochemical and behavioral observations. Brain Research 151, 431442.CrossRefGoogle Scholar
Fujita, S. & Cooper, I. S. (1971). Effects of L-dopa on the H-reflex in Parkinsonism. Journal of the American Geriatric Society 19, 289295.CrossRefGoogle ScholarPubMed
Fuller, R. W., Perry, K. W. & Molloy, B. B. (1975). Effect of 3-(p- trifluoromethyl -phenoxy)-n-methyl -3- phenylpropylamine on the depletion of brain serotonin by 4-chioro- amphetamine. Journal of Pharmacology and Experimental Therapeutics 193, 796803.Google Scholar
Geber, J. & Dupelj, M. (1977). The effect of L-dopa on the spinal monosynaptic mass reflex. Experentia 33, 10741075.CrossRefGoogle ScholarPubMed
Glotzner, F. L. & Mattke, D. J. (1972). The action of neuroleptic drugs on the motor system in man. Pharmakopsychiatrie Neuro-Psychopharmakologie 5, 8293.CrossRefGoogle Scholar
Goode, D. J., Meltzer, H. Y., Crayton, J. W. & Mazura, T. A. (1977). Physiological abnormalities of the neuromuscular systems in schizophrenia. Schizophrenia Bulletin 3, 121138.CrossRefGoogle ScholarPubMed
Goode, D. J., Meltzer, H. Y. & Mazura, T. A. (1979). Hoffmann reflex abnormalities in psychotic patients. Biological Psychiatry 14, 95110.Google ScholarPubMed
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 23, 5662.Google ScholarPubMed
Herbison, G. J. (1973). H-reflex in patients with Parkinsonism: effect of levodopa. Archives of Physical Medicine and Rehabilitation 54, 291–295, 301.Google ScholarPubMed
Hugon, M. (1973). Methodology of the Hoffmann reflex in man. In New Developments in Electromyography and Clinical Neurophysiology, Vol. 3 (ed. Desmedt, J.), pp. 277293. S. Karger: Basel.Google Scholar
Klawans, H. L. & Margolin, D. I. (1975). Amphetamine-induced dopaminergic hypersensitivity in guinea pigs. Archives of General Psychiatry 32, 725732.CrossRefGoogle ScholarPubMed
McLeod, J. G. & Walsh, J. C. (1972). H-reflex studies in patients with Parkinson‘s disease. Journal of Neurology, Neurosurgery, and Psychiatry 35, 7780.Google ScholarPubMed
Magladery, J. W. (1955). Some observations on spinal reflexes in man. Pflügers Archives 261, 301321.CrossRefGoogle ScholarPubMed
Magladery, J. W., Teasdale, R. D., Park, A. M. & Languth, H. W. (1952). Electrophysiological studies of reflex activity in patients with lesions of the nervous system. Bulletin of the Johns Hopkins Hospital 91, 219244.Google ScholarPubMed
Meltzer, H. Y. (1979). Biology of schizophrenia subtypes: a review and proposal for method of study. Schizophrenia Bulletin 5, 460479.CrossRefGoogle ScholarPubMed
Meltzer, H. Y. & Stahl, S. M. (1976). The dopamine hypothesis of schizophrenia: a review. Schizophrenia Bulletin 2, 1976.CrossRefGoogle ScholarPubMed
Meltzer, H. Y., Young, M., Metz, J., Fang, V. S., Schyve, P. M. & Arora, R. C. (1979). Extrapyramidal side effects and increased serum prolactin following fluoxetine, a new antidepressant. Journal of Neural Transmission 45, 165175.CrossRefGoogle ScholarPubMed
Olsen, P. Z. & Diamantopoulos, E. (1967). Excitability of spinal motor neurons in normal subjects and patients with spasticity, Parkinsonian rigidity, and cerebellar hypotonia. Journal of Neurology, Neurosurgery, and Psychiatry 30, 325331.Google ScholarPubMed
Overall, J. E. & Gorham, D. R. (1962). The Brief Psychiatric Rating Scale. Psychological Reports 10, 799812.CrossRefGoogle Scholar
Sastry, P. S. R. & Sinclair, J. G. (1976). Serotonin involvement in the blockade of bulbospinal inhibition of the spinal monosynaptic reflex. Brain Research 115, 427436.CrossRefGoogle ScholarPubMed
Sax, D. S., Johnson, T. L. & Feldman, R. G. (1977). L-Dopa effects on H-reflex recovery in Parkinson‘s disease. Annals of Neurology 2, 120124.CrossRefGoogle Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977). Research Diagnostic Criteria. Biometrics Research: New York.Google Scholar
Wing, J. K., Birley, J. L. T., Cooper, J. E., Graham, P. & Isaacs, A. D. (1967). Reliability of a procedure of measuring and classifying ‘Present Psychiatric State’. British Journal of Psychiatry 113, 499515.CrossRefGoogle ScholarPubMed
Wong, T. T., Horng, J. S., Bymaster, F. P., Hauser, K. L. & Molloy, B. B. (1974). A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethyl-phenoxy)-n- methyl-3-phenylpropylamine. Life Sciences 15, 471479.CrossRefGoogle Scholar
Yap, C-B. (1967). Spinal segmental and long-loop reflexes on spinal motoneurone excitability in spasticity and rigidity. Brain 90, 887896.CrossRefGoogle Scholar