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Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder

Published online by Cambridge University Press:  04 December 2018

Cassandra M. J. Wannan Open the ORCID record for Cassandra M. J. Wannan [Opens in a new window] ,
Vanessa L. Cropley ,
M. Mallar Chakravarty ,
Tamsyn E. Van Rheenen ,
Sam Mancuso ,
Chad Bousman ,
Ian Everall ,
Patrick D. McGorry ,
Christos Pantelis Open the ORCID record for Christos Pantelis [Opens in a new window]  and
Cali F. Bartholomeusz
Cassandra M. J. Wannan*
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia The Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia The Cooperative Research Centre for Mental Health, Melbourne, Australia North Western Mental Health, Melbourne Health, Parkville, VIC, Australia
Vanessa L. Cropley
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia
M. Mallar Chakravarty
Affiliation:
Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada
Tamsyn E. Van Rheenen
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia
Sam Mancuso
Affiliation:
Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
Chad Bousman
Affiliation:
Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, AB, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada Alberta Children's Hospital Research Institute, Calgary, AB, Canada
Ian Everall
Affiliation:
The Cooperative Research Centre for Mental Health, Melbourne, Australia Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia Department of Electrical and Electronic Engineering, Centre for Neural Engineering, University of Melbourne, South Carlton, Victoria, Australia Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK Florey Institute for Neuroscience & Mental Health, Parkville, VIC, Australia
Patrick D. McGorry
Affiliation:
Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia
Christos Pantelis
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia The Cooperative Research Centre for Mental Health, Melbourne, Australia North Western Mental Health, Melbourne Health, Parkville, VIC, Australia Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia Department of Electrical and Electronic Engineering, Centre for Neural Engineering, University of Melbourne, South Carlton, Victoria, Australia Florey Institute for Neuroscience & Mental Health, Parkville, VIC, Australia
Cali F. Bartholomeusz
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia The Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia
*
Author for correspondence: Cassandra M. J. Wannan, E-mail: cwannan@student.unimelb.edu.au
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Abstract

Background

While previous studies have identified relationships between hippocampal volumes and memory performance in schizophrenia, these relationships are not apparent in healthy individuals. Further, few studies have examined the role of hippocampal subfields in illness-related memory deficits, and no study has examined potential differences across varying illness stages. The current study aimed to investigate whether individuals with early and established psychosis exhibited differential relationships between visuospatial associative memory and hippocampal subfield volumes.

Methods

Measurements of visuospatial associative memory performance and grey matter volume were obtained from 52 individuals with a chronic schizophrenia-spectrum disorder, 28 youth with recent-onset psychosis, 52 older healthy controls, and 28 younger healthy controls.

Results

Both chronic and recent-onset patients had impaired visuospatial associative memory performance, however, only chronic patients showed hippocampal subfield volume loss. Both chronic and recent-onset patients demonstrated relationships between visuospatial associative memory performance and hippocampal subfield volumes in the CA4/dentate gyrus and the stratum that were not observed in older healthy controls. There were no group by volume interactions when chronic and recent-onset patients were compared.

Conclusions

The current study extends the findings of previous studies by identifying particular hippocampal subfields, including the hippocampal stratum layers and the dentate gyrus, that appear to be related to visuospatial associative memory ability in individuals with both chronic and first-episode psychosis.

Keywords

CANTABdentate gyrusfirst-episode psychosishippocampal subfieldshippocampusmemoryschizophreniavisuospatial associative memory
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 14 , October 2019 , pp. 2452 - 2462
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

*

Joint last author.

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