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Management of psychiatric adverse events with immunotherapy with interferon-alfa

Published online by Cambridge University Press:  18 September 2015

A.R. Van Gool ,
W.H.J. Kruit ,
J.J. Cornelissen ,
L. Berk ,
A.M.M. Eggermont  and
M. Bannink
A.R. Van Gool*
Affiliation:
University Hospital Rotterdam - Daniel Oncology Clinic, Department of Psychosocial Oncology
W.H.J. Kruit
Affiliation:
University Hospital Rotterdam - Daniel Oncology Clinic, Department of Internal Oncology
J.J. Cornelissen
Affiliation:
University Hospital Rotterdam - Daniel Oncology Clinic, Department of Hematology
L. Berk
Affiliation:
Albert Schweitzer Hospital, Department of Internal Medicine, Zwijndrecht
A.M.M. Eggermont
Affiliation:
University Hospital Rotterdam - Daniel Oncology Clinic, Department of Surgical Oncology
M. Bannink
Affiliation:
University Hospital Rotterdam - Daniel Oncology Clinic, Department of Psychosocial Oncology
*
University Hospital Rotterdam - Daniel Oncology Clinic, Department of Psychosocial Oncology, P.O. Box 5201, 3008 AE Rotterdam, The Netherlands
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Summary

Immunotherapy with interferon-alfa has become standard therapy in selected patients with viral hepatitis and chronic myelogenous leukemia. In addition, it is used in a variety of other diseases, both as standard therapy and in clinical trials. Its use is expected to expand in the following decade. Interferon can cause (severe) neuropsychiatric side effects. These side effects are discussed. Adequate management of these side effects is important, as is close collaboration between the oncologist and the psychiatrist. The cornerstone of management is patient education: this prevents interruption of therapy by patients who were not warned for neuropsychiatric side effects. Furthermore, patients should report in case of rapidly arising mood disorders. Interferon-alfa induced mood disorder is reported to be treatable. Three case descriptions illustrate this, but also illustrate some limits to successful treatment.

Keywords

interferonpsychiatricside effects
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 11 , Issue 4 , December 1999 , pp. 120 - 124
Copyright
Copyright © Cambridge University Press 1999

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References

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