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Brain Lesions Manifesting as Psychiatric Disorders: Eight Cases

Published online by Cambridge University Press:  07 November 2014

Adomas Bunevicius ,
Vytenis Pranas Deltuva ,
Daiva Deltuviene ,
Arimantas Tamasauskas  and
Robertas Bunevicius
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Abstract

Sometimes patients with organic brain lesions in neurologically silent brain areas might present only with psychiatric symptoms, such as depression, anxiety disorders, schizophrenia, anorexia nervosa, or cognitive dysfunction. This study presents eight cases of patients with brain lesions (four cases of meningiomas, one case of intracerebral cysts, one case of anaplastic oligodendroglioma, one case of multiform glioblastoma, and one case of occlusive hydrocephalus) who, for a significant period of time, were diagnosed and treated for psychiatric disorders (three cases of Alzheimer's disease, two cases of schizoaffective disorder, one case of schizophrenia, one case of depression, and one case of organic emotional lability disorder). When neurologic symptoms developed, they underwent neuroimaging studies and organic brain lesions were diagnosed. Further treatment required neurosurgical interventions. These cases show that brain tumors can be neurologically silent for a sufficient period of time and manifest as psychiatric disorders.

Type
Case Report
Information
CNS Spectrums , Volume 13 , Issue 11 , November 2008 , pp. 950 - 958
Copyright
Copyright © Cambridge University Press 2008

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References

REFERENCES

1.Jamieson, RC, Wells, CE. Manic psychosis in a patient with multiple metastatic brain tumors. J Clin Psychiatry. 1979;40:280–283.Google Scholar
2.Gross, RA, Herridge, P. A manic like illness associated with right frontal arteriovenous malformation. J Clin Psychiatry. 1988;49:119–120.Google Scholar
3.Binder, RL. Neurologically silent brain tumors in psychiatric hospital admissions: three cases and a review. J Clin Psychiatry. 1983;44:94–97.Google ScholarPubMed
4.Gupta, RK, Kumar, R. Benign brain tumours and psychiatric morbidity: a 5-years retrospective data analysis. Aust NZ J Psychiatry. 2004;38:316–319.CrossRefGoogle ScholarPubMed
5.Uribe, VM. Psychiatric symptoms and brain tumor. Am Fam Physician. 1986;34:95–98.Google ScholarPubMed
6.Meyers, CA, Hess, KR. Multifaceted end points in brain tumor clinical trials: cognitive deterioration precedes MRI progression. Neuro Oncol. 2003;5:89–95.CrossRefGoogle ScholarPubMed
7.Moise, D, Madhusoodanan, S. Psychiatric symptoms associated with brain tumors: a clinical enigma. CNS Spectr. 2006;11:28–31.Google ScholarPubMed
8.Kocher, R, Linder, M, Stula, D. Primary brain tumors in psychiatry [German]. Schweiz Arch Neurol Neurochir Psychiatr. 1984;135:217–227.Google ScholarPubMed
9.Madhusoodanan, S, Danan, D, Moise, D. Psychiatric manifestations of brain tumors: diagnostic implications. Expert Rev Neurother. 2007;7:343–349.CrossRefGoogle ScholarPubMed
10.Hollister, LE, Boutros, N. Clinical use of CT and MR scans in psychiatric patients. J Psychiatry Neurosci. 1991;16:194–198.Google Scholar
11.The ICD-10 Classification of Mental and Behavioural Disorders; Clinical Descriptions and Diagnostic Guidelines. Geneva, Switzerland: World Health Organization; 1992.Google Scholar
12.DeAngelis, LM. Brain tumors. N Engl J Med. 2001;344:114–123.CrossRefGoogle ScholarPubMed
13.Gilman, S. Imaging the brain. Second of two parts. N Engl J Med. 1998;338:889–896.CrossRefGoogle ScholarPubMed
14.Hirayasu, Y, Shenton, ME, Salisbury, DF, et al.Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry. 1998;155:1384–1391.CrossRefGoogle ScholarPubMed
15.Onitsuka, T, Shenton, ME, Salisbury, DF, et al.Middle and inferior temporal gyms gray matter volume abnormalities in chronic schizophrenia: an MRI study. Am J Psychiatry. 2004;161:1603–1611.CrossRefGoogle Scholar
16.Kasai, K, Shenton, ME, Salisbury, DF, et al.Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry. 2003;60:766–775.CrossRefGoogle ScholarPubMed
17.Khong, SY, Leach, J, Greenwood, C. Meningioma mimicking puerperal psychosis. Obstet Gynecol. 2007;109:515–516.CrossRefGoogle ScholarPubMed
18.Harris, CP, Townsend, JJ, Brockmeyer, DL, et al.Cerebral granular cell tumor occurring with glioblastoma multiforme, case report. Surg Neurol. 1991;36:202–206.CrossRefGoogle ScholarPubMed
19.Maiuri, F, Iaconetta, G, Sardo, L, et al.Peduncular hallucinations associated with large posterior fossa meningiomas. Clin Neurol Neurosurg. 2002;104:41–43.CrossRefGoogle ScholarPubMed
20.van Breemen, MS, Wilms, EB, Vecht, CJ. Epilepsy in patients wlth brain tumours: epidemiology, mechanisms, and management. Lancet Neurol. 2007;6:421–430.CrossRefGoogle Scholar
21.Wilne, SH, Ferris, RC, Nathwani, A, et al.The presenting features of brain turnours, a review of 200 cases. Arch Dis Child. 2006;91:502–506.CrossRefGoogle Scholar
22.Beers, MH, Porter, RS, eds. The Merck Manual of Diagnosis and Therapy. 18th ed. Whitehouse Station, NJ: Merck Research Laboratories; 2006.Google Scholar
23.Oreskovic, NM, Strother, CG, Zibners, LM. An unusual case of a central nervous system tumor presenting as a ch~ef complaint of depression. Pediatr Emerg Care. 2007;23:486–488.CrossRefGoogle Scholar
24.Spence, SA, Taylor, DG, Hirsch, SR. Depressive dlsorder due to craniopharyngioma. J R Soc Med. 1995;88:637–638.CrossRefGoogle ScholarPubMed
25.Bostantjopoulou, S, Katsarou, Z, Petridis, A. Relapsing hemiparkinsonism due to recurrent meningioma. Parkinsonism Relat Disord. 2007;13:372–374.CrossRefGoogle ScholarPubMed
26.Adhiyaman, V, Meara, J. Meningioma presenting as bilateral parkinsonism. Age Ageing. 2003;32:456–458.CrossRefGoogle ScholarPubMed
27.Thynne, K. Normal pressure hydrocephalus. J Neurosci Nurs. 2007;39:27–32.CrossRefGoogle ScholarPubMed
28.Vacca, V. Diagnosis and treatment of idiopathic normal pressure hydrocephalus. J Neurosci Nurs. 2007;39:107–111.CrossRefGoogle ScholarPubMed
29.Duinkerke, A, Williams, MA, Rigamonti, D, et al.Cognitive recovery in idiopathic normal pressure hydrocephalus after shunt. Cogn Behav Neurol. 2004;17:179–184.CrossRefGoogle ScholarPubMed
30.Chaudhry, P, Kharkar, S, Heidler-Gary, J, et al.Characteristics and reversibility of dementia in Normal Pressure Hydrocephalus. Behav Neurol. 2007;18:149–158.CrossRefGoogle ScholarPubMed
31.Iddon, JL, Pickard, JD, Cross, JJ, et al.Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study. J Neurol Neurosurg Psychiatry. 1999;67:723–732.CrossRefGoogle ScholarPubMed
32.Thomann, PA, Wustenberg, T, Pantel, J, et al.Structural changes of the corpus callosum in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord. 2006;21:215–220.CrossRefGoogle ScholarPubMed
33.Frisoni, GB, Testa, C, Zorzan, A, et al.Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry. J Neurol Neurosurg Psychiatry. 2002;73:657–664.CrossRefGoogle ScholarPubMed
34.Chaim, TM, Duran, FL, Uchida, RR, et al.Volumetric reduction of the corpus callosum in Alzheimer's disease in vivo as assessed with voxel-based morphometry. Psychiatry Res. 2007;154:59–68.CrossRefGoogle ScholarPubMed
35.Mainio, A, Hakko, H, Niemelä, A, et al.The effect of brain tumour laterality on anxiety levels among neurosurgical patients. J Neurol Neurosurg Psychiatry. 2003;74:1278–1282.CrossRefGoogle ScholarPubMed
36.Pringle, AM, Taylor, R, Whittle, IR. Anxiety and depression in patients with an intracranial neoplasm before and after tumour surgery. Br J Neurosurg. 1999;13:46–51.CrossRefGoogle ScholarPubMed