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Investigation of the Component Processes Involved in Verbal Declarative Memory Function in Bipolar Disorder: Utility of the Hopkins Verbal Learning Test-Revised

Published online by Cambridge University Press:  29 May 2014

Tamsyn E. Van Rheenen*
Affiliation:
Brain and Psychological Sciences Research Centre (BPsyC), School of Health Sciences, Swinburne University, John St, Melbourne, Australia Cognitive Neuropsychology Laboratory, Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital and Monash University, Melbourne, Australia
Susan L. Rossell
Affiliation:
Brain and Psychological Sciences Research Centre (BPsyC), School of Health Sciences, Swinburne University, John St, Melbourne, Australia Cognitive Neuropsychology Laboratory, Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital and Monash University, Melbourne, Australia
*
Correspondence and reprint requests to: Tamsyn Van Rheenen, Cognitive Neuropsychiatry Laboratory, Monash Alfred Psychiatry Research Centre (MAPrc), Level 4, 607 St Kilda Rd, Melbourne, VIC 3004, Australia. E-mail: tvanrheenen@swin.edu.au

Abstract

Evidence suggests that standard learning and recall indexes are sensitive markers of verbal declarative memory ability in bipolar disorder (BD), but no study has examined performance across the full range of component process measures on the Hopkins Verbal Learning Test (HVLT-R) in a BD cohort. As the HVLT-R is part of a widely used battery of cognitive functioning backed by the U.S. Federal Drug Administration as the accepted battery for use in pro-cognitive trials assessing cognitive-enhancing drugs in the related disorder schizophrenia, estimating the utility of its measures in BD is important. Forty-nine BD patients and 51 healthy controls completed the HVLT-R, which was scored for 13 variables of interest, across 4 indices: recall and learning, recognition, strategic organization, and errors. BD patients had greater difficulty in learning the HVLT-R word list compared to controls. They also demonstrated impairment in delayed recall/recognition. There were no differences between the groups in terms of their slope of learning, retrieval index, retention percentage, semantic or serial clustering, errors, or level of retrieval. This pattern was consistent across symptomatic and euthymic patients. The HVLT-R has some utility in characterizing the component processes involved in memory function in BD, such that memory impairments appear to be attributable to deficient encoding processes during the acquisition phase of learning. In the case of planning pro-cognitive clinical trials, the encoding deficits in BD observed here may be sensitive enough to potentially respond to medications designed to enhance the verbal memory performance. (JINS, 2014, 20, 1–9)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 2014 

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References

Arts, B., Jabben, N., Krabbendam, L., & van Os, J. (2008). Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychological Medicine, 38, 771785. doi:10.1017/S0033291707001675 CrossRefGoogle ScholarPubMed
August, S. M., Kiwanuka, J. N., McMahon, R. P., & Gold, J. M. (2012). The MATRICS Consensus Cognitive Battery (MCCB): Clinical and cognitive correlates. Schizophrenia Research, 134, 7682. doi:http://dx.doi.org/10.1016/j.schres.2011.10.015 CrossRefGoogle ScholarPubMed
Balanzá-Martínez, V., Rubio, C., Selva-Vera, G., Martinez-Aran, A., Sánchez-Moreno, J., Salazar-Fraile, J., … Tabarés-Seisdedos, R. (2008). Neurocognitive endophenotypes (Endophenocognitypes) from studies of relatives of bipolar disorder subjects: A systematic review. Neuroscience and Biobehavioral Reviews, 32, 14261438.Google Scholar
Balanzá-Martínez, V., Tabarés-Seisdedos, R., Selva-Vera, G., Martínez-Arán, A., Torrent, C., Salazar-Fraile, J., …Gómez-Beneyto, M. (2005). Persistent cognitive dysfunctions in bipolar I disorder and schizophrenic patients: A 3-year follow-up study. Psychotherapy and Psychosomatics, 74, 113119.CrossRefGoogle ScholarPubMed
Bearden, C. E., Glahn, D. C., Monkul, E. S., Barrett, J., Najt, P., Kaur, S., Soares, J. C. (2006). Sources of declarative memory impairment in bipolar disorder: Mnemonic processes and clinical features. Journal of Psychiatric Research, 40, 4758.Google Scholar
Benedict, R. (2007). Brief Visuospatial Memory Test-Revised professional manual. Odessa, FL: Psychological Assessment Resources, Inc.Google Scholar
Benedict, R. H. B., Schretlen, D., Groninger, L., & Brandt, J. (1998). Hopkins Verbal Learning Test – Revised: Normative data and analysis of inter-form and test-retest reliability. The Clinical Neuropsychologist, 12, 4355. doi:10.1076/clin.12.1.43.1726 CrossRefGoogle Scholar
Blumenfeld, R. S., & Ranganath, C. (2007). Prefrontal cortex and long-term memory encoding: An integrative review of findings from neuropsychology and neuroimaging. The Neuroscientist, 13, 280291. doi:10.1177/1073858407299290 Google Scholar
Bora, E., Yucel, M., & Pantelis, C. (2009). Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. Journal of Affective Disorders, 113, 120.Google Scholar
Brandt, J., & Benedict, R. (2001). Hopkins Verbal Learning Test-Revised: Professional Manual. Lutz, FL: Psychological Assessment Resources.Google Scholar
Buchanan, R. W., Keefe, R. S. E., Umbricht, D., Green, M. F., Laughren, T., & Marder, S. R. (2011). The FDA-NIMH-MATRICS guidelines for clinical trial design of cognitive-enhancing drugs: What do we know 5 years later? Schizophrenia Bulletin, 37, 12091217. doi:10.1093/schbul/sbq038 CrossRefGoogle ScholarPubMed
Burdick, K. E., Goldberg, T. E., Cornblatt, B. A., Keefe, R. S., Gopin, C. B., DeRosse, P., … Malhotra, A. K. (2011). The MATRICS consensus cognitive battery in patients with bipolar I disorder. Neuropsychopharmacology, 36, 15871592.CrossRefGoogle ScholarPubMed
Deckersbach, T., McMurrich, S., Ogutha, J., Savage, C. R., Sachs, G., & Rauch, S. L. (2004). Characteristics of non-verbal memory impairment in bipolar disorder: The role of encoding strategies. Psychological Medicine, 34, 823832. doi:doi:10.1017/S0033291703001685 CrossRefGoogle ScholarPubMed
Deckersbach, T., Savage, C. R., Reilly-Harrington, N., Clark, L., Sachs, G., & Rauch, S. L. (2004). Episodic memory impairment in bipolar disorder and obsessive–compulsive disorder: The role of memory strategies. Bipolar Disorders, 6, 233244. doi:10.1111/j.1399-5618.2004.00118.x Google Scholar
Elvevåg, B., Fisher, J. E., Weickert, T. W., Weinberger, D. R., & Goldberg, T. E. (2004). Lack of false recognition in schizophrenia: A consequence of poor memory? Neuropsychologia, 42, 546554. doi:http://dx.doi.org/10.1016/j.neuropsychologia.2003.08.013 Google Scholar
Ferrier, I. N., Stanton, B., Kelly, T., & Scott, J. (1999). Neuropsychological function in euthymic patients with bipolar disorder. The British Journal of Psychiatry, 175, 246251. doi:10.1192/bjp.175.3.246 Google Scholar
Foster, P. S., Drago, V., Crucian, G. P., Rhodes, R. D., Shenal, B. V., & Heilman, K. M. (2009). Verbal learning in Alzheimer’s disease: Cumulative word knowledge gains across learning trials. Journal of the International Neuropsychological Society, 15, 730739. doi:10.1017/s1355617709990336 Google Scholar
Gaines, J. J., Shapiro, A., Alt, M., & Benedict, R. H. B. (2006). Semantic clustering indexes for the Hopkins Verbal Learning Test-revised: Initial exploration in elder control and dementia groups. Applied Neuropsychology, 13, 213222. doi:10.1207/s15324826an1304_2 Google Scholar
Gogos, A., Joshua, N., & Rossell, S. L. (2010). Use of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to investigate group and gender differences in schizophrenia and bipolar disorder. Australian & New Zealand Journal of Psychiatry, 44, 220229.Google Scholar
Martin, A., & Chao, L. L. (2001). Semantic memory and the brain: Structure and processes. Current Opinion in Neurobiology, 11, 194201. doi:http://dx.doi.org/10.1016/S0959-4388(00)00196-3 Google Scholar
Martinez-Aran, A., Vieta, E., Torrent, C., Sanchez-Moreno, J., Goikolea, J. M., Salamero, M., …Ayuso-Mateos, J. L. (2007). Functional outcome in bipolar disorder: The role of clinical and cognitive factors. Bipolar Disorders, 9, 103113. doi:10.1111/j.1399-5618.2007.00327.x Google Scholar
Miotto, E. C., Savage, C. R., Evans, J. J., Wilson, B. A., Martins, M. G. M., Iaki, S., … Amaro, E. (2006). Bilateral activation of the prefrontal cortex after strategic semantic cognitive training. Human Brain Mapping, 27, 288295. doi:10.1002/hbm.20184 Google Scholar
Montgomery, S. A., & Asberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382389.CrossRefGoogle ScholarPubMed
Robinson, J. L., Bearden, C. E., Monkul, E. S., Tordesillas-Gutiérrez, D., Velligan, D. I., Frangou, S., … Glahn, D. C. (2009). Fronto-temporal dysregulation in remitted bipolar patients: An fMRI delayed-non-match-to-sample (DNMS) study. Bipolar Disorders, 11, 351360. doi:10.1111/j.1399-5618.2009.00703.x CrossRefGoogle ScholarPubMed
Robinson, L. J., & Ferrier, I. N. (2006). Evolution of cognitive impairment in bipolar disorder: A systematic review of cross-sectional evidence. Bipolar Disorders, 8, 103116.Google Scholar
Robinson, L. J., Thompson, J. M., Gallagher, P., Goswami, U., Young, A. H., Ferrier, I. N., & Moore, P. B. (2006). A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. Journal of Affective Disorders, 93, 105115.Google Scholar
Rossell, S. L., & David, A. S. (2006). Are semantic deficits in schizophrenia due to problems with access or storage? Schizophrenia Research, 82, 121134.Google Scholar
Rossell, S. L., Rabe-Hesketh, S., Shapleske, J., & David, A. S. (1999). Is semantic fluency differentially impaired in schizophrenic patients with delusions? Journal of Clinical and Experimental Neuropsychology, 21, 629642.Google Scholar
Sánchez-Morla, E. M., Barabash, A., Martínez-Vizcaíno, V., Tabarés-Seisdedos, R., Balanzá-Martínez, V., Cabranes-Díaz, J. A., … Gómez, J. L. S. (2009). Comparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patients. Psychiatry Research, 169, 220228. doi:10.1016/j.psychres.2008.06.032 CrossRefGoogle ScholarPubMed
Schretlen, D. J., Cascella, N. G., Meyer, S. M., Kingery, L. R., Testa, S. M., Munro, C. A., … Pearlson, G. D. (2007). Neuropsychological functioning in bipolar disorder and schizophrenia. Biological Psychiatry, 62, 179186.Google Scholar
Schulze, K. K., Walshe, M., Stahl, D., Hall, M. H., Kravariti, E., Morris, R., … Bramon, E. (2011). Executive functioning in familial bipolar I disorder patients and their unaffected relatives. Bipolar Disorders, 13, 208216. doi:10.1111/j.1399-5618.2011.00901.x Google Scholar
Sheehan, D. V., Lecrubier, Y., Harnett Sheehan, K., Amorim, P., Janavs, J., Weiller, E., … Dunbar, G. C. (1998). The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry, 59, 2233.Google Scholar
Snodgrass, J. G., & Corwin, J. (1988). Pragmatics of measuring recognition memory: Applications to dementia and amnesia. Journal of Experimental Psychology: General, 117, 3450. doi:10.1037/0096-3445.117.1.34 CrossRefGoogle ScholarPubMed
Solé, B., Bonnin, C. M., Torrent, C., Balanzá-Martínez, V., Tabarés-Seisdedos, R., Popovic, D., … Vieta, E. (2012). Neurocognitive impairment and psychosocial functioning in bipolar II disorder. Acta Psychiatrica Scandinavica, 125, 309317. doi:10.1111/j.1600-0447.2011.01759.x CrossRefGoogle ScholarPubMed
Squire, L., & Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253, 13801386. doi:10.1126/science.1896849 CrossRefGoogle ScholarPubMed
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004). The medial temporal lobe. Annual Review of Neuroscience, 27, 279306. doi:10.1146/annurev.neuro.27.070203.144130 Google Scholar
Strakowski, S. M., Adler, C. M., Almeida, J., Altshuler, L. L., Blumberg, H. P., Chang, K. D., … Townsend, J. D. (2012). The functional neuroanatomy of bipolar disorder: A consensus model. Bipolar Disorders, 14, 313325. doi:10.1111/j.1399-5618.2012.01022.x Google Scholar
Tan, E. J., & Rossell, S. L. (2014). Building a neurocognitive profile of thought disorder in schizophrenia using a standardized test battery. Schizophrenia Research, 152, 242245. doi:http://dx.doi.org/10.1016/j.schres.2013.11.001 Google Scholar
van Gorp, W. G., Altshuler, L., Theberge, D. C., & Mintz, J. (1999). Declarative and procedural memory in bipolar disorder. Biological Psychiatry, 46, 525531.CrossRefGoogle ScholarPubMed
Van Rheenen, T. E., & Rossell, S. L. (2013a). An empirical evaluation of the MATRICS consensus cognitive battery in bipolar disorder. Bipolar Disorders. doi:10.1111/bdi.12134 Google Scholar
Van Rheenen, T. E., & Rossell, S. L. (2013b). Genetic and neurocognitive foundations of emotion abnormalities in bipolar disorder. Cognitive Neuropsychiatry, 18, 168207. doi:10.1080/13546805.2012.690938 Google Scholar
Whalley, H. C., McKirdy, J., Romaniuk, L., Sussmann, J., Johnstone, E. C., Wan, H. I., … Hall, J. (2009). Functional imaging of emotional memory in bipolar disorder and schizophrenia. Bipolar Disorders, 11, 840856. doi:10.1111/j.1399-5618.2009.00768.x Google Scholar
White, T., & Stern, R. A. (2003). Neuropsychological Assessment Battery: Psychometric and technical manual. Lutz, FL: Psychological Assessment Resources.Google Scholar
Woods, S. P., Rippeth, J. D., Conover, E., Gongvatana, A., Gonzalez, R., Carey, C. L., … Grant, I. (2005). Deficient Strategic Control of Verbal Encoding and Retrieval in Individuals With Methamphetamine Dependence. Neuropsychology, 19, 3543. doi:10.1037/0894–4105.19.1.35 Google Scholar
Woods, S. P., Scott, J. C., Dawson, M. S., Morgan, E. E., Carey, C. L., Heaton, R. K., & Grant, I. (2005). Construct validity of Hopkins Verbal Learning Test—Revised component process measures in an HIV-1 sample. Archives of Clinical Neuropsychology, 20, 10611071. doi:http://dx.doi.org/10.1016/j.acn.2005.06.007 Google Scholar
Yatham, L. N., Torres, I. J., Malhi, G. S., Frangou, S., Glahn, D. C., Bearden, C. E., … Chengappa, K. N. R. (2010). The International Society for Bipolar Disorders–Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disorders, 12, 351363. doi:10.1111/j.1399-5618.2010.00830.x CrossRefGoogle ScholarPubMed
Young, R., Biggs, J., Ziegler, V., & Meyer, D. (1978). A rating scale for mania: Reliability, validity and sensitivity. The British Journal of Psychiatry, 133, 429435. doi:10.1192/bjp.133.5.429 Google Scholar