Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-25T17:54:15.597Z Has data issue: false hasContentIssue false
  • English
  • Français

A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

Published online by Cambridge University Press:  29 December 2020

Ester Solter ,
Jason C. Kwong ,
Aaron Walton ,
Norelle Sherry ,
Benjamin P. Howden ,
M. Lindsay Grayson ,
David Schwartz ,
Elizabeth Temkin ,
Sammy Frenk  and
Yehuda Carmeli
...Show all authors
Ester Solter
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Jason C. Kwong
Affiliation:
Microbilogical Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, University of Melbourne, Victoria, Australia Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia
Aaron Walton
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Barwon Health, Geelong, Victoria, Australia
Norelle Sherry
Affiliation:
Microbilogical Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, University of Melbourne, Victoria, Australia Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia
Benjamin P. Howden
Affiliation:
Microbilogical Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, University of Melbourne, Victoria, Australia Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia
M. Lindsay Grayson
Affiliation:
Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, University of Melbourne, Victoria, Australia
David Schwartz
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Elizabeth Temkin
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Sammy Frenk
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Yehuda Carmeli
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Mitchell J. Schwaber*
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
*
Author for correspondence: Mitchell J. Schwaber, E-mail: mitchells@tlvmc.gov.il
Get access Rights & Permissions [Opens in a new window]

Abstract

We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase–producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase–producing isolates to be monophyletically derived from a common ancestor.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 42 , Issue 9 , September 2021 , pp. 1124 - 1127
Check for updates
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Savard, P, Perl, TM. Combating the spread of carbapenemases in Enterobacteriaceae: a battle that infection prevention should not lose. Clin Microbial Infect 2014;20:854–861.CrossRefGoogle Scholar
Schwaber, MJ, Lev, B, Israeli, A, et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis 2011;52:848–855.Google Scholar
Navon-Venezia, S, Leavitt, A, Schwaber, MJ, et al. First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States. Antimicrob Agents Chemother 2009;53:818–820.10.1128/AAC.00987-08CrossRefGoogle ScholarPubMed
Adler, A, Shklyar, M, Schwaber, MJ, et al. Introduction of OXA-48–producing Enterobacteriaceae to Israeli hospitals by medical tourism. J Antimicrob Chemother 2011; 66: 2763–2766.CrossRefGoogle Scholar
Lachish, T, Elimelech, M, Arieli, N, Adler, A, Rolain, JM, Assous, MV. Emergence of New Delhi metallo-beta-lactamase in Jerusalem, Israel. Int J Antimicrob Agents 2012;40:566–567.CrossRefGoogle ScholarPubMed
Solter, E, Adler, A, Rubinovitch, B, et al. Israeli national policy for carbapenem-resistant Enterobacteriaceae screening, carrier isolation, and discontinuation of isolation. Infect Control Hosp Epidemiol 2018;39:85–89.CrossRefGoogle ScholarPubMed
Adler, A, Miller-Roll, T, Assous, MV, et al. A multicenter study of the clonal structure and resistance mechanism of KPC-producing Escherichia coli isolates in Israel. Clin Microbial Infect 2015;21:230–235.10.1016/j.cmi.2014.10.008CrossRefGoogle ScholarPubMed
Carattoli, A, Bertini, A, Villa, L, Falbo, V, Hopkins, KL, Threlfall, EJ. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 2005;63:219–228.CrossRefGoogle ScholarPubMed
Won, SY, Munoz-Price, LS, Lolans, K, et al. Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 2011;53:532–540.10.1093/cid/cir482CrossRefGoogle ScholarPubMed
Ben-David, D, Masarwa, S, Fallach, N, et al. Success of a national intervention in controlling carbapenem-resistant Enterobacteriaceae in Israel’s long-term care facilities. Clin Infect Dis 2019;68:964–971.CrossRefGoogle ScholarPubMed
Protonotariou, E, Poulou, A, Politi, L, et al. Hospital outbreak due to a Klebsiella pneumoniae ST147 clonal strain co-producing KPC-2 and VIM-1 carbapenemases in a tertiary teaching hospital in Northern Greece. Int J Antimicrob Agents 2018;52:331–337.CrossRefGoogle Scholar
Roer, L, Overballe-Petersen, S, Hansen, F, et al. Escherichia coli sequence type 410 is causing new international high-risk clones. mSphere 2018;3:pii:e00337-18.10.1128/mSphere.00337-18CrossRefGoogle Scholar
Supplementary material: File

Solter et al. Supplementary Materials

Solter et al. Supplementary Materials
Download Solter et al. Supplementary Materials(File)
File 1.4 MB