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Preconception paternal/maternal BMI and risk of small/large for gestational age infant in over 4·7 million Chinese women aged 20–49 years: a population-based cohort study in China

Published online by Cambridge University Press:  21 February 2022

Tonglei Guo ,
Ying Yang ,
Jiajing Jia ,
Yuzhi Deng ,
Yuanyuan Wang ,
Ya Zhang ,
Hongguang Zhang ,
Yuan He ,
Jun Zhao  and
Zuoqi Peng
...Show all authors
Tonglei Guo
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China
Ying Yang*
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China Graduate School of Peking Union Medical College, Building 18, No. 9, Dongdan Santiao, Dongcheng District, 100730 Beijing, People’s Republic of China
Jiajing Jia
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China Graduate School of Peking Union Medical College, Building 18, No. 9, Dongdan Santiao, Dongcheng District, 100730 Beijing, People’s Republic of China
Yuzhi Deng
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China Graduate School of Peking Union Medical College, Building 18, No. 9, Dongdan Santiao, Dongcheng District, 100730 Beijing, People’s Republic of China
Yuanyuan Wang
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China
Ya Zhang
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China
Hongguang Zhang
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China
Yuan He
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China Graduate School of Peking Union Medical College, Building 18, No. 9, Dongdan Santiao, Dongcheng District, 100730 Beijing, People’s Republic of China
Jun Zhao
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China
Zuoqi Peng
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China
Qiaomei Wang
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No. 1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, People’s Republic of China
Haiping Shen
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No. 1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, People’s Republic of China
Yiping Zhang
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No. 1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, People’s Republic of China
Donghai Yan
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No. 1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, People’s Republic of China
Xu Ma*
Affiliation:
National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China National Human Genetic Resource Center, No. 12, Dahuisi Road, Haidian District, 100081 Beijing, People’s Republic of China Graduate School of Peking Union Medical College, Building 18, No. 9, Dongdan Santiao, Dongcheng District, 100730 Beijing, People’s Republic of China
*
* Corresponding authors: Ying Yang, email angela-yy65@hotmail.com; Xu Ma, email nfpcc_ma@163.com
* Corresponding authors: Ying Yang, email angela-yy65@hotmail.com; Xu Ma, email nfpcc_ma@163.com
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Abstract

Evidence of couples’ BMI and its influence on birth weight is limited and contradictory. Therefore, this study aims to assess the association between couple’s preconception BMI and the risk of small for gestational age (SGA)/large for gestational age (LGA) infant, among over 4·7 million couples in a retrospective cohort study based on the National Free Pre-pregnancy Checkups Project between 1 December 2013 and 30 November 2016 in China. Among the live births, 256 718 (5·44 %) SGA events and 506 495 (10·73 %) LGA events were documented, respectively. After adjusting for confounders, underweight men had significantly higher risk (OR 1·17 (95 % CI 1·15, 1·19)) of SGA infants compared with men with normal BMI, while a significant and increased risk of LGA infants was obtained for overweight and obese men (OR 1·08 (95 % CI 1·06, 1·09); OR 1·19 (95 % CI 1·17, 1·20)), respectively. The restricted cubic spline result revealed a non-linear decreasing dose–response relationship of paternal BMI (less than 22·64) with SGA. Meanwhile, a non-linear increasing dose–response relationship of paternal BMI (more than 22·92) with LGA infants was observed. Moreover, similar results about the association between maternal preconception BMI and SGA/LGA infants were obtained. Abnormal preconception BMI in either women or men were associated with increased risk of SGA/LGA infants, respectively. Overall, couple’s abnormal weight before pregnancy may be an important preventable risk factor for SGA/LGA infants.

Keywords

BMISmall for gestational ageLarge for gestational agePreconceptionCohort study
Type
Research Article
Information
British Journal of Nutrition , Volume 129 , Issue 9 , 14 May 2023 , pp. 1645 - 1655
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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