Abstract
Novel PdII and PtII complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and 1H-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their PdII and PtII complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.
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Offiong, O.E., Nfor, E., Ayi, A.A. et al. Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes. Transition Metal Chemistry 25, 369–373 (2000). https://doi.org/10.1023/A:1007055304150
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DOI: https://doi.org/10.1023/A:1007055304150