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Breast cancer in Australian women under the age of 40

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Abstract

Objectives: A case-control-family study of breast cancer in women under the age of 40 was carried out in Melbourne and Sydney, Australia, from 1992 to 1995 to determine the risk factors for these women. Subjects included 467 incident cases identified by state cancer registries and 408 population-based controls. Methods: All participants completed a structured risk-factor questionnaire and family pedigree during an in-person interview. Where possible, cancers in first- and second-degree relatives were verified. Results: Multiple logistic regression analysis showed that the strongest risk factor for breast cancer was a family history of the disease - having at least one affected first-degree relative trebled the risk (relative risk [RR] = 3.3, 95 percent confidence interval [CI] = 1.9-5.8). Risk increased with height by three percent (standard error [SE] of one percent) per cm, and after adjusting for height, there was evidence for a decreased risk in women weighing 73 kg or more. There was an increased risk of breast cancer after the first full-term birth (RR = 1.8, CI = 1.0-3.5) but this risk fell by 30 percent (SE = 11 percent) with each subsequent livebirth. Conclusions: The effects of other reproductive factors and oral contraceptive use, although not nominally significant, were in accord with published findings from similar studies in young women. This study of Australian women has indicated that some risk factors for breast cancer in women under age 40 differ from those reported for older women either in direction (e.g., weight) or relative importance (e.g., family history).

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References

  1. Coates M, McCredie M, Armstrong BK. Cancer in New South Wales, Incidence and Mortality, 1993. Sydney, NSW (Australia): NSW Cancer Council, 1996.

    Google Scholar 

  2. Giles G, Whitfield K, Thursfield V, Staples M. Cancer in Victoria 1993, Canstat. Melbourne, Victoria (Australia): Anti-Cancer Council of Victoria, 1996.

    Google Scholar 

  3. Velentgas P, Daling J. Risk factors for breast cancer in younger women. Monogr Natl Cancer Inst 1994; 16: 15–22.

    Google Scholar 

  4. Pharaoh PDP, Day NE, Duffy S, Easton DF, Ponder BAJ. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer 1997; 71: 800–9.

    Google Scholar 

  5. Ursin G, Longnecker MP, Haile RW, Greenland S. A meta analysis of body mass index and risk of premenopausal breast cancer. Epidemiology 1995; 6: 137–41.

    Google Scholar 

  6. Thune I, Brenn T, Lund E, Gaard M. Physical activity and the risk of breast cancer. N Engl J Med 1997; 336: 1269–75.

    Google Scholar 

  7. Coogan PF, Newcomb PA, Clapp RW, Trentham-Dietz A, Baron JA, Longnecker MP. Physical activity in usual occupation and risk of breast cancer (United States). Cancer Causes Control 1997; 8: 626–31.

    Google Scholar 

  8. Chen CL, White E, Malone KE, Daling JR. Leisure-time physical activity in relation to breast cancer among young women (Washington, United States). Cancer Causes Control 1997; 8: 77–84.

    Google Scholar 

  9. Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK. Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 1994; 86: 1403–8.

    Google Scholar 

  10. CollaborativeGroup on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet 1996; 347: 1713–27.

    Google Scholar 

  11. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the 17q-linked breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66–71.

    Google Scholar 

  12. Wooster R and 40 others. Identification of the breast cancer susceptibility gene BRCA2. Nature (Lond) 1995; 378: 789–92.

    Google Scholar 

  13. Hopper J, Giles GG, McCredie M, Boyle P. Background, rationale and protocol for a case-control-family study of breast cancer. The Breast 1994; 3: 79–86.

    Google Scholar 

  14. WorldHealth Organization. International Classification of Diseases, Ninth Revision. Geneva, Switzerland: WHO, 1997.

    Google Scholar 

  15. Statisticsand Epidemiology Research Corporation. EGRET Software Package. Seattle, WA (USA): SERC, 1990.

    Google Scholar 

  16. NumericalAlgorithms Group Ltd. The Generalized Linear Interactive Modeling (GLIM) System. Oxford, UK: Royal Statistical Society, 1987.

    Google Scholar 

  17. Breslow NE, Day NE. Statistical Methods in Cancer Research. Volume 1: The Analysis of Case-Control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.

    Google Scholar 

  18. Easton DF, Peto J, Babiker AG. Floating absolute risk: an alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference. Stat Med 1991; 10: 1025–35.

    Google Scholar 

  19. Hunter DJ, Willett WC. Diet, body size, and breast cancer. Epidemiol Rev 1993; 15: 110–32.

    Google Scholar 

  20. Bruzzi P, Negri E, LaVecchia C, et al. Short term increase of breast cancer after full term pregnancy. Br Med J 1988; 297: 1096–8.

    Google Scholar 

  21. Negri E, LaVecchia C, Bruzzi P, et al. Risk factors for breast cancer: pooled results from three Italian case-control studies. Am J Epidemiol 1988; 128: 1207–15.

    Google Scholar 

  22. Leon DA, Carpenter LM, Broeders MJM, Gunnarskog J, Murphy MFG. Breast cancer in Swedish women before age 50: evidence of a dual effect of completed pregnancy. Cancer Causes Control 1995; 6: 283–91.

    Google Scholar 

  23. Kelsey JL. Breast cancer epidemiology: summary and future directions. Epidemiol Rev 1993; 15: 256–63.

    Google Scholar 

  24. Hsieh C-c, Pavia M, Lambe M, et al. Dual effect of parity on breast cancer risk. Eur J Cancer 1994; 30A: 969–73.

    Google Scholar 

  25. Albrektsen G, Heuch I, Kvåle G. The short-term and long term effect of a pregnancy on breast cancer risk: a prospective study of 802,457 parous Norwegian women. Br J Cancer 1995; 72: 480–4.

    Google Scholar 

  26. Russo J, Tay LK, Russo IH. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 1982; 2: 5–73.

    Google Scholar 

  27. Pike MC, Krailo MD, Henderson BE, Casegrande JT, Hoel DG.'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer. Nature 1983; 303: 767–70.

    Google Scholar 

  28. Hunter DJ, Spiegelman D, Adami HO, et al. Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer. Cancer Causes Control 1997; 8: 49–56.

    Google Scholar 

  29. Sattin RW, Rubin GL, Webster LA, et al, and the Cancer and Steroid Hormone Study. Family history and the risk of breast cancer. JAMA 1985; 253, 1908–13.

    Google Scholar 

  30. Theis B, Boyd N, Lockwood G, Tritchler D. Accuracy of family cancer history in breast cancer patients. Eur J Cancer Prev 1994; 3: 321–7.

    Google Scholar 

  31. Swanson CA, Coates RJ, Schoenberg JB, et al. Body size and breast cancer risk among women under age 45 years. Am J Epidemiol 1996; 143: 698–706.

    Google Scholar 

  32. Gerber M. Re: Body size and breast cancer risk among women under age 45 years. Am J Epidemiol 1997, 145: 669.

    Google Scholar 

  33. Li CI, Malone KE, White E, Daling JR. Age when maximum height is reached as a risk factor for breast cancer among young U.S. women. Epidemiology 1997; 8: 559–65.

    Google Scholar 

  34. Swanson CA, Potischman NA, Brinton LA. Re: Body size and breast cancer risk among women under age 45 years. Am J Epidemiol 1997; 145: 669–70.

    Google Scholar 

  35. UKNational Case-Control Study Group. Breast feeding and risk of breast cancer in young women. Br Med J 1993; 307: 17–20.

    Google Scholar 

  36. Enger SM, Ross RK, Henderson BE, Bernstein L. Breastfeeding history, pregnancy experience and risk of breast cancer. Br J Cancer 1997; 76: 118–23.

    Google Scholar 

  37. Brinton LA, Potischman NA, Swanson CA, et al. Breastfeeding and breast cancer risk. Cancer Causes Control 1995; 6: 199–208.

    Google Scholar 

  38. Newcombe PA, Storer BE, Longnecker MP, et al. Lactation and a reduced risk of premenopausal breast cancer. N Eng J Med 1994; 330: 81–7.

    Google Scholar 

  39. Skegg DCG. Potential for bias in case-control studies of oral contraceptives and breast cancer. Am J Epidemiol 1988; 127: 205–12.

    Google Scholar 

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McCredie, M.R., Dite, G.S., Giles, G.G. et al. Breast cancer in Australian women under the age of 40. Cancer Causes Control 9, 189–198 (1998). https://doi.org/10.1023/A:1008886328352

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